Description: The concentration-dependent absorption behaviour of uranium was investigated with surviving intestinalsegments of rat jejunums, using an ex-vivo model. The results showed a monotonic slightly nonlinearincrease in absorption as uranium concentrations increased. This trend was observed over the entire concentrationrange tested. In the lower concentration range a slower linear ascent was observed while asteeper linear ascent was found for the higher concentration range. Statistical fit was only slightly poorerfor an exponential function in the range of lower values and a logarithmic function in the range of highervalues. The proportion of uranium absorbed expressed as percent of uranium concentrations in the perfusionsolutions followed a monotonically increasing trend from 20 to around 200 lg/l uranium in theperfusion solutions, which thereafter appears to reach a plateau, as further increase towards concentrationsaround 400 lg/l is not substantial. The uranium concentration administered had no effect on thevitality and consequently the functionality of the intestinal segments, measured in terms of active glucosetransport. The results imply that uranium concentrations of more than 20 lg/l in drinking water,for example, could lead to elevated absorption rates and thus to higher internal exposures to considerwhen setting of Guideline values in this concentration range.Quelle: http://www.sciencedirect.com
Global identifier:
Doi(
"10.60810/openumwelt-308",
)
Origin: /Bund/UBA/openUMWELT
Tags: Resorption ? Uran ? Blei ? Ratte ? Trinkwasser ? Effektkonzentration ? REACH ? Richtwert ? Dünndarm ?
License: other-closed
Language: Englisch/English
Issued: 2014-01-01
Time ranges: 2014-01-01 - 2014-01-01
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