Description: This article introduces ´Tox-Box, a joint research project designed to develop a holistic approach towards a harmonized testing strategy for exposure- and hazard-based risk management of anthropogenic trace substances in drinking water to secure a long-term drinking water supply. The main task of the Tox-Box consortium is to enhance the existing health-related indicator value concept (German: GOW-Konzept - Gesundheitlicher Orientierungswert) through development and prioritization of additional end point-related testing strategies for genotoxicity, neurotoxicity, germ cell damage, and endocrine effects. In this context, substance-specific modes of action will be identified and characterized. Toxicological data collected by the 12 Tox-Box subprojects will be evaluated and weighted to structure a hierarchical testing strategy for an improved risk assessment. A technical guidance document for exposure and hazard-based risk management of anthropogenic trace substances in drinking water will eventually be prepared.<BR>© enveurope.com
Global identifier:
Doi(
"10.60810/openumwelt-775",
)
Origin: /Bund/UBA/openUMWELT
Tags: Endokrine Wirkung ? Genotoxizität ? Neurotoxizität ? Daten ? Trinkwasser ? Wasserversorgung ? Stoff ? Forschungsprojekt ? Risikomanagement ? Risikobewertung ?
License: other-closed
Language: Englisch/English
Issued: 2013-01-01
Time ranges: 2013-01-01 - 2013-01-01
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