Description: The aim of HELIX is to exploit novel tools and methods (remote sensing/GIS-based spatial methods, omics-based approaches, biomarkers of exposure, exposure devices and models, statistical tools for combined exposures, novel study designs, and burden of disease methodologies), to characterise early-life exposure to a wide range of environmental hazards, and integrate and link these with data on major child health outcomes (growth and obesity, neurodevelopment, immune system), thus developing an Early-Life Exposome approach. HELIX uses six existing, prospective birth cohort studies as the only realistic and feasible way to obtain the comprehensive, longitudinal, human data needed to build this early-life exposome. These cohorts have already collected large amounts of data as part of national and EU-funded projects. Results will be integrated with data from European cohorts (greater than 300,000 subjects) and registers, to estimate health impacts at the large European scale. HELIX will make a major contribution to the integrated exposure concept by developing an exposome toolkit and database that will: 1) measure a wide range of major chemical and physical environmental hazards in food, consumer products, water, air, noise, and the built environment, in pre and postnatal periods; 2) integrate data on individual, temporal, and toxicokinetic variability, and on multiple exposures, which will greatly reduce uncertainty in exposure estimates; 3) determine molecular profiles and biological pathways associated with multiple exposures using omics tools; 4) provide exposure-response estimates and thresholds for multiple exposures and child health; and 5) estimate the burden of childhood disease in Europe due to multiple environmental exposures. This integration of the chemical, physical and molecular environment during critical early-life periods will lead to major improvements in health risk and impact assessments and thus to improved prevention strategies for vulnerable populations.
SupportProgram
Origins: /Bund/UBA/UFORDAT
Tags: Gesundheitsgefährdung ? Biomarker ? Biopharmazeutikum ? Gesundheitsschaden ? Kleinkind ? Kombinationswirkung ? Pharmakokinetik ? Physiologie ? Säugling ? Schadstoffbelastung ? Bundesrepublik Deutschland ? Gesundheitliche Auswirkungen ? Kohortenstudie ? Molekulare Epidemiologie ? Geografisches Informationssystem ? Kind ? Umweltbelastung ? Luftverschmutzung ? Verbraucherprodukt ? Immunsystem ? Analyseverfahren ? Lärmbelastung ? Nervensystem ? Bevölkerungsstruktur ? Chemikalien ? Toxizität ? Epidemiologie ? Wasserverschmutzung ? Wirkungsanalyse ? Biologische Aktivität ? Exposition ? Menschliche Gesundheit ? Europa ? Gesundheitsbezogene Umweltbeobachtung ? Expositionsbewertung ? Gravidität ? Toxikologie ? Ökologischer Faktor ? Bevölkerung ? Ernährung ? Population ? Gebaute Umwelt ? Fernerkundung ? Datenerhebung ? Statistik ? Umwelt und Gesundheit ? Lebensmittel ? Wachstum [biologisch] ? Adipositas ? Zeitverlauf ? Belastungsanalyse ? FP7-ENVIRONMENT ? Lebensabschnitt ? Umweltbedingte Krankheitslast [EBD] ?
License: cc-by-nc-nd/4.0
Language: Deutsch
Time ranges: 2013-01-01 - 2017-12-31
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