Description: Das Projekt "Gemeinschaftsprogramm zur Erforschung von Umwelthormonen und endokrin wirksamen Substanzen" wird vom Umweltbundesamt gefördert und von Eidgenössische Anstalt für Wasserversorgung, Abwasserreinigung und Gewässerschutz durchgeführt. General Information: The development by man of an increasing array of new chemicals and their inevitable release into the environment poses a major threat to ecosystem health. This is particularly true of the aquatic environment, which receives direct discharges of industrial and domestic waste waters as part of man's normal waste disposal system. Recent evidence shows that some of these chemical and effluents can affect wildlife at concentrations much lower than their measured acute toxicity range by specifically interfering with the endocrine system. This can occur by a variety of mechanisms which include mimicry of natural hormones (agonism), blocking hormone receptors (antagonism) and interference with hormone synthesis or metabolism. Evidence of effects at the level of individual organism suggest that these phenomena may be widespread in the aquatic environment but demonstrations of impacts at the level of population, community or ecosystem are rare. Thus, our present state of knowledge implies that endocrine disruption of wildlife may be a widespread and potentially serious environmental problem which will require future management but our knowledge of its true extent and severity is very limited. COMPREHEND is a programme of research to assess the extent of the problem on a Europe-wide basis, to identify the principle components of waste water effluents responsible for endocrine disruption, to search for hard evidence of impacts at the population level and to develop new tools for the early warning of endocrine disrupting activity in effluents and chemicals. It concentrates on the impacts on sexual reproduction in aquatic animals (freshwater, estuarine and coastal) with particular, but not exclusive, reference to fish because the consortium of scientists involved believe that this is the most serious endocrine-disrupting threat to wildlife. Estrogenic mimicry is likely to be an important mechanism in this process and, therefore, a significant proportion of the work programme will be centred around the detection and measurement of estrogenicity of effluents. From recent developments in our understanding of the complexity of estrogen activity within the target tissues, it is argued that reliance on a single screening procedure to detect estrogenicity will not be a reliable predictor of impacts on aquatic ecosystems. Consequently, it is proposed to develop a framework for integrating a range of techniques (chemical, in vitro, in vivo/physiological, life cycle studies, field observations) to assess, with reliability, the potential of an effluent or chemical to impact adversely on aquatic wildlife by interfering with the hormonal control of reproduction. This framework will also act as a generic model for the assessment and management of other forms of endocrine disruption and will include the development ... Prime Contractor: Natural Environment Research Council; Institute of Freshwater Ecology; Ambleside-Cumbria; UK.
SupportProgram
Origin: /Bund/UBA/UFORDAT
Tags: Flussmündung ? Süßwasserfisch ? Endokrine Wirkung ? Antagonistische Wirkung ? Physiologische Wirkung ? Schadstoffgehalt ? Abwassereinleitung ? Abwasserreinigung ? Biologische Wirkung ? Schadstoffwirkung ? Umweltauswirkung ? Mimikry ? Häusliches Abwasser ? Sexuelle Fortpflanzung ? Wildtiermanagement ? Küstengewässer ? Regeltechnik ? Abfallentsorgung ? Chemische Analyse ? Akute Toxizität ? Umweltbelastung ? Wassertier ? Geschlechtshormon ? Feldstudie ? in vitro ? Studie ? Aquatisches Ökosystem ? Abwasserqualität ? Trinkwasser ? Hormon ? Wasserinhaltsstoff ? Gewässerorganismen ? Wasserversorgung ? Wirkungsanalyse ? Wirkungsforschung ? Gewässerschutz ? Biologische Anpassung ? Abwasser ? Frühwarnsystem ? Hormonsystem ? Wildlebende Tiere und Pflanzen ? Endokrin aktive Substanz ? Chemikalien ? Stoffwechsel ? Population ? Lebenszyklus ? Gewebe ? Ökosystem ? In-Vivo ? Screening [Voruntersuchung] ?
License: cc-by-nc-nd/4.0
Language: Deutsch
Time ranges: 1999-01-01 - 2001-12-31
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