Description: Das Projekt "Cytotoxicity of nanoparticles independent from oxidative stress" wird/wurde gefördert durch: European Center for Nanotoxicology (EURO-NanoTox). Es wird/wurde ausgeführt durch: ZMF - Center for Medical Research.The use of nano-sized materials offers exciting new options in technical and medical applications. On the other hand, adverse effects on cells have been reported and may limit their use. In addition to physico-chemical parameters like contamination with toxic elements, fibrous structure and high surface charge, the generation of radical species was identified as key mechanism for cytotoxic action of nanoparticles. The cytotoxic potential of nanoparticles in the absence of radical generation is less well investigated. This study aims to investigate the size-dependent effect of carboxyl polystyrene particles on cells derived from various organs was studied to identify potential adverse effects of these particles. Particles were characterized in different solutions to assess the influence of the medium on size and surface charge. Viability, membrane integrity, apoptosis, proliferation and generation of oxidative stress were investigated. In addition the intracellular localization of the particles was recorded.
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Origin: /Bund/UBA/UFORDAT
Tags: Polystyrol ? Werkstoff ? Textilchemikalien ? Brunnen ? Gebäude ? Stress ? Wirkung ? Zytotoxizität ? Chemikalien ? Rechtsverfahren ? Studie ? Toxizität ? Zelle ? Wirkung ? Nanopartikel ? Membran ? Organ ? Partikel ? Verunreinigung ? SONSTIG ? Art [Spezies] ? EINSATZ ? ENTWICKLUNGSFAEHIGKEIT ? Gebühr [Abgabe] ? LOESUNG ? MECHANISMEN ? MEDIZINISCH ? NEU ? OBERFLAECHE ? Ortsbestimmung ? POTENZIAL ? Radikal [Chemie] ? ABHAENGIG ? Verwertung ? BEWERTEN ? Bemessung ? EINGESCHRAENKT ?
License: cc-by-nc-nd/4.0
Language: Englisch/English
Time ranges: 2007-01-01 - 2008-12-31
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