Organotypic brain slice cultures as alternatives to in-vivo experimentation in the study of brain repair mechanisms (ORCA)

Description: Currently the demand for animal testing is increasing in both the pharmaceutical and academic sectors driven by a vast increase in the numbers of potential new drug targets following the advances in genomic and polemic technologies and new organic synthesis methods. The present proposal will develop specific methodology and new chronic in-vitro models of traumatic brain injury and stroke that allow for the study of neurodegenerative mechanisms as well as mechanisms of brain repair in organotypic brain slice cultures. These systems will present attractive alternatives to comparable in-vivo models for basic and applied research, reducing the need to carry out in-vivo tests. At the same time they will help industry tore fine and improve the selection of compounds, which subsequently must be tested in-vivo before entering clinical trials. Prime Contractor: University Southampton; Southampton; United Kingdom.

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Origins: /Bund/UBA/UFORDAT

Tags: Arzneimittel ? Technologietransfer ? Brunnen ? Vereinigtes Königreich ? Strafrecht ? Vermeidung von Tierversuchen ? Abfallwirtschaft ? Biotechnologie ? Innovation ? Studie ? Technik ? Tierversuch ? Industrie ? Reparatur ? Angewandte Wissenschaft ? Bedarf ? Gesundheit ? Gebiet ? Umweltschutz ? VORSCHLAG ? Auslese ? Vermehrung ? FORTSCHRITTLICH ? GEGENWART ? Gehirn ? HILF ? Life Sciences ? MECHANISMEN ? METHODE ? METHODIK ? NACHFRAGE ? NEU ? POTENZIAL ? SCHAEDIGUNG ? SPEZIFISCH ? Synthese ? UNTERSUCHUNG ? VERBINDUNG ? VERGLEICHBARKEIT ? VORSCHLAEGE ? AKADEMISCH ?

Region: Saxony-Anhalt

Bounding boxes: 11.7333° .. 11.7333° x 52° .. 52°

License: cc-by-nc-nd/4.0

Language: Englisch/English

Organisations

• Keyneurotek A.G., In Vitro Labor (Mitwirkung)
• Kommission der Europäischen Gemeinschaften Brüssel (Finanzielle Förderung)
• Leibniz-Institut für Neurobiologie, Stiftung des Öffentlichen Rechts (Projektverantwortung)
• Neuroscreen A.P.S. (Mitwirkung)
• Smithkline Beecham Plc (Mitwirkung)
• Umweltbundesamt (Bereitstellung)
• Universitet Köbenhavn (Mitwirkung)
• University Southampton (Mitwirkung)
• University of Southern Denmark, University of Odense, Institute Of Medical Biology (Mitwirkung)

Time ranges: 2002-01-01 - 2004-12-31

Status

Aktiv

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