Description: Das Projekt "Untersuchung des Stoffwechsels von Pentachlornitrobenzol (PCNB) und Untersuchungen von Kombinationswirkungen: Schwermetallverbindungen-PCNB; Untersuchung des Stoffwechsels von Pentachlornitrobenzol, Hexachlorbenzol und ihrer Metaboliten" wird/wurde gefördert durch: Deutsche Forschungsgemeinschaft. Es wird/wurde ausgeführt durch: Universität München, Walther-Straub-Institut für Pharmakologie und Toxikologie.Studies on the metabolism of the fungicides HCB and PCNB indicated similarities in their pathways of biotransformation. Sulphur-containig metabolites of both fungicides, such as PCC (N-Acetyl-S-(Pentachlorophenyl) Cysteine), pentachlorothiophenol, pentachlorothioanisole, 1,4-dimercapto-tetrachlorobenzene and/or 4-methylthio-tetrachlorothiophenol, and 1,4-bis (methylthio) tetrachlorobenzene, but also non sulphur-containing metabolites, such as phenols and chlorinated benzenes, are identical. Studies on the metabolism of the mercapturic acid PCC in rabbits and rats revealed the above-mentioned sulphur-containing metabolites which were further metabolized. Of interest was the finding of pentachlorobenzene after administration of pentachlorothiophenol and of 1,2,4,5-tetrachlorobenzene after administration of S,S'-(tetrachloro-p-phenylene) dicysteine, a degradation product of PCNB and of its metabolite 2,3,5,6-tetrachlorothiophenol, respectively, in hexane extracts of excreta by g.l.c. analyses. These results elucidate the mechanisms of reductive dechlorination of HCB and denitration of PCNB. Replacement of one chlorine in HCB or of the nitro group in PCNB by the acetylcysteinyl moiety originating from glutathione leads via PCC to pentachlorothiophenol which forms pentachlorobenzene by reductive desulphuration.
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Origin: /Bund/UBA/UFORDAT
Tags: Pentachlornitrobenzol ? Fungizid ? München ? Hexan ? Phenol ? Aromatischer Kohlenwasserstoff ? Hexachlorbenzol ? Kombinationswirkung ? Schwermetallverbindung ? Pharmakologie ? Stoffwechselprodukt ? Biotransformation ?
Region: Bayern
Bounding boxes: 12.53381° .. 12.53381° x 47.795° .. 47.795°
License: cc-by-nc-nd/4.0
Language: Deutsch
Time ranges: 1981-06-22 - 1982-06-22
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