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ERA-IB 3: MySterI - Novel industrial bioprocesses for production of key valuable steroid precursors from phytosterol

Description: Das Projekt "ERA-IB 3: MySterI - Novel industrial bioprocesses for production of key valuable steroid precursors from phytosterol" wird vom Umweltbundesamt gefördert und von Technische Universität Dortmund, Lehrstuhl für Anlagen- und Prozesstechnik durchgeführt. Project MySterI (Mycobacterial Steroids for Industry) aims to produce high value steroid precursorsusing a novel bioconversion strategy resulting in lower production costs and less cost to the environment. The aim is to convert phytosterols in cheap waste plant material to desired steroidprecursors with engineered strains of fast-growing, saprophytic mycobacteria in single fermentationsteps. The bioconversion of phytosterols has not been widely adopted in the biotechnology industrybecause of problems with microbial strains, process efficiency and therefore poor yield. At the heart of project MySterI is the bioconversion of phytosterols to 3ß-hydroxyandrost-5-ene-17-one (DHEA) orto androst-4-ene-3,17-dione (AD) (intermediary precursor) and then to 11a-hydroxyandrost-4-ene-3,17-dione (11-a-OH-AD) and testosterone. A conceptual downstream processing design methodology will be developed valid for the produced compounds. The evaluation of the production process will be done using key performance indicators (e.g., Separation Cost Indicator, Purification Fingerprints). The robot based conceptual design methodology should merge heuristic methods, automated experiments, statistical methods as well as modeling and simulation to one extensive tool.

Types:
SupportProgram

Origin: /Bund/UBA/UFORDAT

Tags: Dortmund ? Material ? Brunnen ? Pflanzlicher Abfall ? Steroid ? Industrie ? Geschlechtshormon ? Vorläufersubstanz ? Bewertung ? Abfall ? Abscheidung ? Biotechnologie ? Herz ? Produktionskosten ? Produktionstechnik ? Simulation ? Verfahrenstechnik ? Wirkungsgrad ? Reinigung ? Modellierung ? Indikator ? Umwelt ? Planung ? Kosten ? Strategische Aspekte ? Produktion ? INGENIEURWESEN ? NEU ? STATISTISCH ? BEWERTEN ? STROMABWAERTS ? EXPERIMENT ? Genetischer Fingerabdruck ? VERARBEITUNG ? VERBINDUNG ? WERT ? INDUSTRIELL ? EIN ? LEISTUNGSFAEHIGKEIT ? Werkzeug ? METHODE ? METHODIK ? ERGEBNIS ? PROJEKT ?

Region: Nordrhein-Westfalen

Bounding boxes: 6.76339° .. 6.76339° x 51.21895° .. 51.21895°

License: cc-by-nc-nd/4.0

Language: Deutsch

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Time ranges: 2013-03-01 - 2016-09-30

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