Cyanotoxine und oxidativer Stress in aquatischen Makrophyten

Description: In vielen Organismen erfolgt die Biotransformation der cyanobakteriellen Microcystine über die Konjugation an Glutathion. Während der weiteren Biotransformationsprozesse, in welchen das Glutathionkonjugat weiter abgebaut wird, kann es zur Entstehung reaktiver Sauerstoffspezies kommen. Diese aktivieren ein antioxidatives Abwehrsystem, und es werden Enzyme wie die Superoxiddismutase, Katalase, Glutathionperoxidase in ihrer Aktivität gesteigert. Auch der Ascorbat-Glutathion Kreislauf wird beeinflusst. Während der Exposition von Ceratophyllum demersum konnte die Bildung eines Microcystin-LR Glutathionkonjugates nachgewiesen werden, ebenso die Aktivierung von löslichen und mikrosomalen Glutathion STransferasen, die Beeinflussung des Glutathionpools, sowie, die Aktivierung verschiedenster antioxidativer Enzyme.

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Origins: /Bund/UBA/UFORDAT

Tags: Microcystine ? Cyanotoxin ? Cyanobakterien ? Makrophyten ? Stress ? Toxin ? Biotransformation ? Exposition ? Oxidation ? Anthropogener Einfluss ? Organismen ? Stoffkreislauf ? Stoffwechsel ? Bakterienkonjugation ? Ceratophyllum demersum ? Enzym ? Enzymaktivität ? Ertragsbeeinflussung ? Sauerstoffeintrag ? oxidative stress ?

Region: Berlin

License: cc-by-nc-nd/4.0

Language: Deutsch

Organisations

• Forschungsverbund Berlin, Leibniz-Institut für Gewässerökologie und Binnenfischerei (Betreiber*in)
• Umweltbundesamt (Bereitsteller*in)

Time ranges: 2005-01-01 - 2007-12-31

Alternatives

• Language: Englisch/English
  Title: Cyanobacterial toxins and oxidative stress responses in aquatic macrophytes
  Description: In many organisms, biotransformation of toxins takes place via several glutathione-related conjugates. During the biotransformation process in which the toxin and the toxin conjugate are broken down, the formation of reactive oxygen species can occur. These reactive oxygen species activate several antioxidant enzymes such as superoxid dismutase, catalase, and ascorbate peroxidase, and also influence the glutathione-ascorbate cycle. During exposure of the aquatic macrophytes Ceratophyllum demersum a microcystin-LR glutathione-conjugate was formed, glutathione S-transferases were activated, and several antioxidant enzymes were elevated, evidence for the promotion of oxidative stress by microcystins. During exposure of C. demersum to the cyanobacterial toxin microcystin-LR at a concentration of 5.0 myg L-1, elevations of microsomal and cytosolic glutathione S-transferase were measured, showing the initial formation of the glutathione-toxin conjugate. The superoxid dismutase and the hydrogen peroxide level increased, giving evidence for oxidative stress in the aquatic plant. Other reactive oxygen detoxifiying enzymes were also elevated and the glutathione pool, expressed in reduced glutathione and glutathione disulfide concentration, was changed accordingly. https://ufordat.uba.de/UFORDAT/pages/PublicRedirect.aspx?TYP=PR&DSNR=1014471

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