Description: The overall goal of COMPRENDO is to improve our understanding of the effects of endocrine disrupting chemicals (EDCs) on aquatic wildlife and humans, focussing on androgenic and antiandrogenic compounds (AACs). This will help to improve environmental quality standards and also the public health in the European Community. To this end our key objectives are: Characterise the human and environmental exposure to AACs; Determine the impacts of environmentally relevant doses/concentrations of AACs on a wide range of human-relevant models and aquatic species; Develop new biological effect measures and species-specific critical endpoints, including a molecular screen for genomic effects of AACs; Identify common principles of AAC action in different species to develop new animal models for extrapolation to human health; Develop lab cultures for suitable aquatic invertebrates and establish their baseline endocrinology; Characterise the risk originating from AACs in humans and wildlife. The COMPRENDO consortium consists of 13 partners and five subcontractors of 10 European nations (Germany: University of Frankfurt; University Hospital Bonn, Institute for Clinical Biochemistry; Leibniz-Institute of Freshwater Ecology and Inland Fisheries Berlin, U.K.: University of Exeter, University of Brunel; Sweden: University of Lund; Denmark: Technical University of Denmark; France: Bureau de Recherches Geologiques et Minieres; Spain: Consejo Superior de Investigationes Cientificas; Italy: University of Milan, University of Insubria; Greece: University of Ioannina; Poland: University of Gdansk.
Types:
SupportProgram
Origins:
/Bund/UBA/UFORDAT
Tags:
Bonn
?
Milan
?
Antiandrogene Wirkung
?
Androgene Wirkung
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Antihormonelle Wirkung
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Genökologie
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Physiologische Wirkung
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Endokrine Wirkung
?
Berlin
?
Schadstoffwirkung
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Limnisches Ökosystem
?
Dosis-Wirkungs-Beziehung
?
Endokrinologie
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Wassertier
?
Krankenhaus
?
Geschlechtshormon
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Wirbellose
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Endokriner Disruptor
?
Mensch
?
Aquatisches Ökosystem
?
Öffentliche Gesundheit
?
Gewässerorganismen
?
Wirkungsanalyse
?
Phylogenese
?
Biologische Untersuchung
?
Europäische Union
?
Endokrin aktive Substanz
?
Hochrechnung
?
Internationale Zusammenarbeit
?
Ökosystem
?
Forschungskooperation
?
Gesundheitsvorsorge
?
EU-Länder
?
COMPRENDO
?
Phylogenetischer-Ansatz
?
AAC-Androgene-und-antiandrogene-Verbindungen
?
FP5-EESD
?
Region:
Hessen
Bounding boxes:
9° .. 9° x 50.55° .. 50.55°
License: cc-by-nc-nd/4.0
Language: Deutsch
Organisations
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Centre d'analyses et de recherches sur les substances organique (Mitwirkende)
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Kommission der Europäischen Gemeinschaften Brüssel (Geldgeber*in)
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LimnoMar Labor für Limnische, Marine Forschung und Vergleichende Pathologie (Mitwirkende)
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Rijksinstituut voor Volksgezondheid en Milieu (RIVM) (Mitwirkende)
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Ryszard Olejnik (Mitwirkende)
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Umweltbundesamt (Bereitsteller*in)
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Universite Strasbourg (Mitwirkende)
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Universität Frankfurt am Main, Institut für Ökologie, Evolution und Diversität, Abteilung Aquatische Ökotoxikologie (Betreiber*in)
Time ranges:
2002-10-01 - 2006-03-31
Alternatives
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Language: Englisch/English
Title: COMPRENDO - Comparative Research on Endocrine Disrupters: Phylogenetic Approach and Common Principles focussing on Androgenic/Antiandrogenic Compounds
Description: The EU-project COMPRENDO as an interdisciplinary, integrated approach addresses endocrine disruption in human and wildlife species, focussed on androgenic/antiandrogenic compounds (AACs). The project will identify human and environmental exposures to AACs. A variety of human-relevant models (cell lines, tissues, rodents) and wildlife species (amphibians, fish, echinoderms, crustaceans, molluscs) will be exposed to 13 chemicals and various environmental samples to develop new biological effect measures, including a molecular screen for genomic AAC effects. Common principles of AAC action will be identified and new models for the extrapolation on human health developed. Lab cultures of suitable invertebrates will be established and their baseline endocrinology analysed, facilitating the use of these species as standard test organisms. Finally, an evaluation of the risk originating from AACs for humans and wildlife will be performed. The COMPRENDO consortium consists of 13 partners and five subcontractors of 10 European nations (Germany, Denmark, France, Greece, Italy, Poland, Sweden, Spain, The Netherlands as well as U.K). COMPRENDO represents an interdisciplinary specialist team coming from a number of relevant areas, like environmental chemistry, endocrinology, human- and ecotoxicology, aquatic ecology, molecular biology, nutrition sciences, cell biology and genetics.
https://ufordat.uba.de/UFORDAT/pages/PublicRedirect.aspx?TYP=PR&DSNR=1004028
Resources
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