Description: The toxicity of nanoparticles is an issue relevant for occupational health. The available data indicate that the smaller the particle the higher the toxicity. On the other hand, there is a lack of scientific information how surface properties modify particle toxicity. The project aims at studying a specific nanoparticle in unchanged and in two surface-modified versions, respectively. The project studies the impact of surface modifications on the toxicological properties. The experimental set-up will be a 28-day inhalation study according to method b.8 of EC/440/2008 (i.e. OECD 412) in extended form. It is intended to include a 90-d post observation period be able to study the course of selected toxicity markers which describe the toxicological profile of the nanoparticles under consideration.
SupportProgram
Origins: /Bund/UBA/UFORDAT
Tags: Nagetier ? Gesundheitsgefährdung ? Inhalation ? Schadstoffwirkung ? OECD ? Partikelgrößenverteilung ? Staubbelastung ? Struktur-Wirkung-Beziehung ? Versuchstier ? Arbeitshygiene ? Arbeitsschutz ? Daten ? Kausalzusammenhang ? Studie ? Tierversuch ? Toxikologische Bewertung ? Vergleichsanalyse ? Nanopartikel ? Partikel ? Buchgrundstück ? Nanostrukturierung ? Nanotoxizität ? Selektivität ? surface property ?
Region: Niedersachsen
License: cc-by-nc-nd/4.0
Language: Englisch/English
Time ranges: 2009-01-01 - 2012-06-30
Webseite zum Förderprojekt
http://www.baua.de/en/Research/Research-Project/f2246.html (Webseite)Accessed 1 times.