Description: Das Projekt "Endocrine Disruption in Gastropods - Target Identification and Modes of Action" wird/wurde gefördert durch: Hessisches Ministerium für Wissenschaft und Kunst. Es wird/wurde ausgeführt durch: Universität Frankfurt am Main, Institut für Ökologie, Evolution und Diversität, Abteilung Aquatische Ökotoxikologie.Endocrine disrupting chemicals (EDCs) can affect the hormone system of gastropods at low concentrations causing altered fecundity, feminisation or virilisation. However, ecotoxicological research in this area is hampered by the fact that endocrine pathways and modes of action of potential EDCs in gastropods are poorly understood. The ovoviviparous New Zealand mudsnail Potamopyrgus antipodarum is one of the model species used in this project. In this species effects of EDCs manifest in the reproductive performance of the parthenogenic females i.e. estrogenic substances cause an increase in embryo production. However, it is unclear by which mechanisms or modes of actions these effects are mediated because the target molecules for estrogenic substances (e.g. estrogen receptors) are not sufficiently characterised in P. antipodarum. Another effect of EDCs is the imposex phenomenon in female marine gastropods (e.g. the dogwhelk Nucella lapillus and the netted whelk Nassarius reticulatus). Imposex is characterised by the development of male sex organs (penis and/or vas deferens) additionally to the complete female genital tract, but the underlying mechanism is not fully clarified and a matter of a current scientific debate. Hence, the project aims on the identification and characterisation of possible target molecules for EDCs in P. antipodarumand of modes of imposex induction in N. lapillus and N. reticulatus.
SupportProgram
Origin: /Bund/UBA/UFORDAT
Tags: Östrogene Wirkung ? Inn ? Schnecke ? Endokrine Wirkung ? Meeresschnecke ? Embryo ? Ökotoxikologie ? Wirkung ? Geschlechtshormon ? Imposex ? Chemikalien ? Fruchtbarkeit ? Rechtsverfahren ? Geschlecht ? Hormon ? Stoff ? Wirkung ? Forschung ? Organ ? Produktion ? Art [Spezies] ? MECHANISMEN ? PFAD ? POTENZIAL ? PROJEKT ? Rezeptor ? Vermehrung ? WIRKUNGSWEISE ? WISSENSCHAFTLICH ?
Region: Hessen
Bounding boxes: 10.30054° .. 10.30054° x 47.90813° .. 47.90813°
License: cc-by-nc-nd/4.0
Language: Englisch/English
Time ranges: 2009-01-01 - 2012-12-31
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