Nach hamburgischem Landesrecht werden Veröffentlichungen durch Abdruck im Hamburgischen Gesetz- und Verordnungsblatt vorgenommen. Rechtsverbindlich ist deshalb ausschließlich die gedruckte Ausgabe des Hamburgischen Gesetz- und Verordnungsblattes Teile I und II (Amtlicher Anzeiger). Eine Inhaltssuche kann nur über die Internetseite der <a href="http://www.luewu.de/anzeiger/">Firma Lütcke & Wulff</a> erfolgen.
The project 4G-PHOTOCAT allies the expertise of 7 academic and 3 industrial partners from 5 EU countries (Germany, United Kingdom, Czech Republic, Poland, and Finland) and 2 ASEAN countries (Malaysia and Vietnam) for the development of a novel generation of low-cost nano-engineered photocatalysts for sunlight-driven water depollution. Through rational design of composites in which the solar light-absorbing semiconductors are coupled to nanostructured redox co-catalysts based on abundant elements, the recombination of photogenerated charges will be suppressed and the rate of photocatalytic reactions will be maximized. In order to achieve fabrication of optimal architectures, advanced chemical deposition techniques with a high degree of control over composition and morphology will be employed and further developed. Furthermore, novel protocols will be developed for the implementation of the photocatalysts into a liquid paint, allowing for the deposition of robust photoactive layers onto flat surfaces, without compromising the photoactivity of immobilized photocatalysts. Such paintable photoreactors are envisaged particularly as low-cost devices for detoxification of water from highly toxic persistent organic pollutants which represent a serious health issue in many remote rural areas of Vietnam and other countries. The 4G-PHOTOCAT project will provide novel scientific insights into the correlation between compositional/structural properties and photocatalytic reaction rates under sunlight irradiation, as well as improved fabrication methods and enhanced product portfolio for the industrial partners. Finally, 4G-PHOTOCAT will lead to intensified collaboration between scientists working at the cutting edge of synthetic chemistry, materials science, heterogeneous photocatalysis, theoretical modelling, and environmental analytics, as well as to unique reinforcement of cooperation between scientists and industry partners from EU and ASEAN countries.
Marine life makes a substantial contribution to the economy and society of Europe. VECTORS will elucidate the drivers, pressures and vectors that cause change in marine life, the mechanisms by which they do so, the impacts that they have on ecosystem structures and functioning, and on the economics of associated marine sectors and society. VECTORS will particularly focus on causes and consequences of invasive alien species, outbreak forming species, and changes in fish distribution and productivity. New and existing knowledge and insight will be synthesised and integrated to project changes in marine life, ecosystems and economies under future scenarios for adaptation and mitigation in the light of new technologies, fishing strategies and policy needs. VECTORS will evaluate current forms and mechanisms of marine governance in relation to the vectors of change. Based on its findings, VECTORS will provide solutions and tools for relevant stakeholders and policymakers, to be available for use during the lifetime of the project. The project will address a complex array of interests comprising areas of concern for marine life, biodiversity, sectoral interests, regional seas, and academic disciplines as well as the interests of stakeholders. VECTORS will ensure that the links and interactions between all these areas of interest are explored, explained, modelled and communicated effectively to the relevant stakeholders. The VECTORS consortium is extremely experienced and genuinely multidisciplinary. It includes a mixture of natural scientists with knowledge of socio-economic aspects, and social scientists (environmental economists, policy and governance analysts and environmental law specialists) with interests in natural system functioning. VECTORS is therefore fully equipped to deliver the integrated interdisciplinary research required to achieve its objectives with maximal impact in the arenas of science, policy, management and society.
There is enormous economic potential for the application of embedded optimization technologies in embedded systems design. Recent advances in the performance of embedded hardware platforms, in combination with fundamental improvements in optimization theory and algorithms, have opened the door to widespread applications over the next decade. Embedded optimization will enable huge energy and resource savings, increased safety, and improved fault detection across a wide a range of industrial applications in the mechatronic, automotive, process control and aerospace sectors. In order to realize the full potential of optimization in embedded systems, their design must also be supported by a focussed set of tools enabling the rapid transfer of novel high-performance algorithms to practical applications. The EMBOCON consortium will enable widespread application of real-time optimization in embedded systems through: - Tailoring of customized numerical algorithms to increase their robustness and efficiency on embedded systems - Enabling real-time optimization on cheap industry-standard hardware platforms - Defining a common user interface for optimization technologies to facilitate technology transfer to industry - Performing challenging case studies in cooperation with industrial partners to demonstrate technological maturity. The EMBOCON consortium will strengthen a network of world-leading academic and industrial partners with complementary expertise in control, optimization and embedded systems in a range of industrial applications. Particular emphasis is placed on close collaboration between mathematical algorithm developers, control theorists, hardware specialists and industrial application engineers. The network will consolidate and extend Europe's position as the world research leader in these areas and foster strong collaborative links between European academia and industry. Prime Contractor: University London, Imperial College of Science, Technology and Medicine, Faculty of Engineering, Level 2 Faculty; London; United Kingdom.
Small molecule natural products are a prolific source of inspiration for the development of new drugs, and essential tools in basic biomedical research as probes of biological functions. The contribution of academic laboratories in natural products discovery has been essential. The limiting factor of traditional approaches in bioactivity-directed natural product research has been the tedious process of purification and identification of active molecules from a highly complex extract matrix. Recent technological advances enable substantial improvements in efficiency via a consequential miniaturization of the screening and discovery process, and automation of certain process steps. The aim of the project is to discover small molecule natural products leads from plants and fungi acting against clinically relevant and/or emerging targets in important disease areas. The targets have been selected on the basis of specific criteria, such as (i) novelty and importance of target; (ii) lack of specific/selective inhibitors; (iii) need for enhancement of structural diversity of ligands; (iv) difficulty/impossibility to use rational drug discovery approaches; (v) access to animal models. Indications include CNS (selective GABA-A receptor agonists), inflammation and cancer (modulation of angiogenesis and lymphangiogenesis, inhibition of PI3 kinases). In addition, a screening for hERG channel inhibition will be carried out as the currently most critical anti-target in drug discovery & development. An extract library and a technology platform for the miniaturized discovery of natural products will be used. The library consists of currently 1000 plant and fungal extracts. An ethnomedicine-based focussed sub-library will be specifically tested for GABAA receptor agonistic properties. All process steps in the screening and consecutive lead identification are miniaturized, in part automated, and based on the 96-well microtiter footprint. Most of the assays are via external collaborations, and some assays involving cell signalling are established in-house. Prioritized extracts are submitted to HPLC-based activity profiling with microtiter-based fractionation of column effluent, and simultaneous on-line spectroscopic (PDA, ion-trap ESI and APCI-MS, and ESI-TOF) analysis. Compound dereplication and identification is supported by off-line microprobe NMR spectroscopy. Around the active target molecules, structurally related compounds will be characterized to generate small 'virtual' libraries for preliminary structure activity relationships. Calculation of physico-chemical data and secondary bioassays will characterize leads, and shortlisted compounds will be tested in vivo for proof of concept. For this purpose, compounds of interest are isolated in a targeted manner in amounts of up to several hundred mg.
Objective: observatoryNANO brings together leading EU organizations who collectively have expertise in the technological; economic; societal/ethical; health, safety, and environmental analysis of nanotechnologies. Its primary aim is to develop appropriate methodologies to link scientific and technological development of nanotechnologies with socio-economic impacts. Both of these aspects will be enhanced by expert opinion, making this project unique in providing relevant web-based reports in a common format across all sectors, considered by all criteria, and widely publicized. observatoryNANO will become an industry leading and opinion forming catalyst for nanotechnology in the EU. The purpose is to avoid the exaggerated socio-economic impact of nanotechnologies and place developments in a realistic time-frame. It will present a reliable, complete, and responsible science-based and economic expert analysis of peer-reviewed literature, patents, national funding strategies, investment trends, and markets; in combination with information derived from questionnaires, interviews and workshops with academic and industry leaders, investors, and other key stakeholders.
Objective: The proposed project is designed to address the problem of pollution of the environment by road vehicles as denned under the Thematic Priority 1.6.2, Sustainable Surface Transport relating to the Work Programme 'Integrating and strengthening the European Research Area'. The research activities of the consortium will be based around state of the art developments in the area of optical fibre sensor and intelligent instrumentation technology to formulate a system for on line monitoring of exhaust emissions from road vehicles. The application of this technology to resolving the problems of atmospheric pollutants and their regional impacts is therefore highly appropriate to the issue identified in the thematic roadmap i.e. 'New technologies and concepts for all surface transport modes'. The consortium which will execute the research programme comprises six members from four EC member states. They include four academic institutions, an SME and an end user (a major European car manufacturer). Their combined expertise and knowledge of the technological and business issues will facilitate the rapid development of the technology into a demonstratable prototype within the three year lifetime of the project. The project's technical objectives are summarised as follows: -. To set up laboratory based test facilities such that the sensor systems may be characterised in a precisely controlled and reproducible manner. Therefore, individual parameters such as optical absorption and scattering may be studied in isolation as well as collectively.. To isolate and identify the optical signals arising from contaminants present in the complex mixtures of exhaust systems of a wide range of vehicles using advanced and novel optical fibre based spectroscopie interrogation techniques. To develop novel optical fibre sensors which are miniature and robust in their construction and may be fitted...
There is widespread concern about how production and use of chemicals affect the environment. Yet food production and benefits of chemical products are vital for the functioning of European societies. In order to ensure sustainable use, EU regulations require extensive risk assessment before a chemical is approved for use. Current risk assessments focus on risk at the level of individual organisms, but according to EU directives the protection goal aims at achieving sustainable populations. Population-level effects depend not only on exposure and toxicity, but also on important ecological factors that are impossible to fully address empirically. Mechanistic effect models (MEMs) enable the integration of these factors, thus increasing the ecological relevance of risk assessments as well as providing vital understanding of how chemicals interact with ecosystems. Such understanding is crucial for improving risk mitigation strategies and ecosystem management. So far, however, regulators and industry have lacked understanding of the potential benefits that MEMs can deliver, and academics have been inconsistent in the approaches applied. This has led to scepticism about models, preventing a wider use of MEMs in risk assessment. Examples clearly demonstrating the power of MEMs for risk assessment are urgently needed, and industry, academia and regulatory authorities across Europe need scientists that are trained in both MEMs and regulatory risk assessment. CREAM will develop and experimentally validate a suite of MEMs for organisms relevant for chemical risk assessments. The consortium includes the main sectors involved (industry, academia, regulators) and will formulate Good Modelling Practice that will be followed in all individual projects, thus leading to consistency and transparency. CREAM will provide world class training for the next generation of ecological modellers, emphasizing transparency and rigorous model evaluation as core elements of the modelling process.
Natural products remain an important source for drugs and a source of inspiration for medicinal chemists for the design of synthetic drugs and probes for the study of biological functions. The contribution of academic laboratories in natural products discovery has been substantial. The limiting factor of pharmaceutical natural product research has been with the tedious process of purification and identification of the lead molecules from the highly complex crude extract. Recent technological advances enable now a miniaturization of the screening and discovery process for natural product leads. The proposal here is for the purchase of a 500 MHz NMR spectrometer specifically equipped for the measurement of mass limited samples. It includes a recently commercialized 1 mm probe and autosampler and is capable of recording 1D and 2D NMR spectra with microgram (20-100 myg) amounts of natural products and synthetic drug-like molecules. The spectrometer is configured to fit into the technology platforms and the workflows of the Drug Screening Group of the Swiss Tropical Institute and the Institute of Pharmaceutical Biology. The instrument shall be used for various interdisciplinary projects of the two principal applicants and for a consortium which is being established. The major use will be for HPLC-based lead discovery in the area of Alzheimer's disease, Malaria, and neglected tropical diseases. The instrument will also be employed for metabolic fingerprinting of selected plants and phytomedicines. A third application will be in the analysis of compound libraries from external sources which are screened by the applicants in the context of the principal projects. An NMR instrument with this configuration is currently not in operation at a Swiss university. It is the missing link in a technology platform established at the laboratories of the two applicants. This platform should enable a paradigm shift in the way how natural product leads are identified, namely by miniaturizing the entire process of screening, separation and lead identification to the microgram level. A significant gain in efficiency of the discovery process and, thus, in research productivity, both qualitative and quantitative, is anticipated. The equipment will also be of interest to all those scientists in the biomedical sciences who need structural information from mass limited samples such as, for example drug metabolites.
Currently the demand for animal testing is increasing in both the pharmaceutical and academic sectors driven by a vast increase in the numbers of potential new drug targets following the advances in genomic and polemic technologies and new organic synthesis methods. The present proposal will develop specific methodology and new chronic in-vitro models of traumatic brain injury and stroke that allow for the study of neurodegenerative mechanisms as well as mechanisms of brain repair in organotypic brain slice cultures. These systems will present attractive alternatives to comparable in-vivo models for basic and applied research, reducing the need to carry out in-vivo tests. At the same time they will help industry tore fine and improve the selection of compounds, which subsequently must be tested in-vivo before entering clinical trials. Prime Contractor: University Southampton; Southampton; United Kingdom.
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