Die nachhaltige Produktion wichtiger Chemikalien, Lebensmittel- und Pharmazeutikakomponenten ist von hoher Bedeutung für die Gesellschaft und die Umwelt. Biotechnologische Produktionssysteme stellen eine sinnvolle Alternative zu den bisherigen, meist chemischen, Verfahren da. Die biotechnologische Produktionssysteme basieren jedoch bisher meist auf der Verwertung von Zuckern. Zucker, die aus Pflanzen gewonnen werden, benötigen kultivierbares Land, das mehr und mehr zur Gewinnung von Nahrungsmitteln benötigt wird. Methanol - mit einer weltweiten Produktionskapazität von mehr als 46 Millionen Tonnen pro Jahr - gilt als attraktiver alternativer Rohstoff für die biotechnologische Produktion von Spezial-, Fein- und Basischemikalien oder Kraftstoffen. Dies gilt insbesondere für den EU-Markt, wo die industrielle Biotechnologie noch durch strikte Preis- und Nutzungsregularien sowie Importlimitierungen von Agrargütern wie Mais oder Zucker behindert ist. Die Methanolversorgung kann sowohl auf fossilen, als auch auf erneuerbaren Ressourcen basieren, was es als flexiblen und nachhaltigen Rohstoff auszeichnet. In dem Projekt PROMYSE werden zum ersten Mal synthetisch-biologische Prinzipien für die Entwicklung von Zellfabriken angewendet um Methanol als generellen Rohstoff für die Produktion von Spezial- und Feinchemikalien verfügbar zu machen. Produktseitig liegt der Hauptfokus auf der Substanzklasse der Terpenoide.
The consortium will discover and carry to the stage of development candidates, plant derived small molecules with potential as new cosmetic and agrochemical agents. These compounds will derive from plants originating from major biodiversity hotspots in Europe, Africa, Latin America, and the Asia-Pacific region. The starting point of the project will be a diversity-oriented natural product library of 500 compounds from the existing compound repositories of three project partners. Screening of this compound library in assay panels for agrochemical (antifungal, herbicidal, insecticidal) and cosmetic properties (UV-protection, anti-aging, anti-hyper-pigmentation) will rapidly identify promising scaffolds. This knowledge will serve as entry points for a chemotaxonomy and chemo-diversity oriented collection of plants which are thought to contain structural variants and decorations of these scaffolds. A liquid library of 3600 extracts will be generated and screened. Stringent prioritization and profiling procedures will generate 300 compounds as focused sub-libraries around the privileged scaffolds. A state-of-the-art technology platform for miniaturized natural product discovery will be used for the purpose. Evaluation of these sub-libraries will lead to 30 compounds which will undergo advanced testing to qualify 5 compounds as development candidates for novel agrochemical and/or cosmetic agents with new or improved properties over existing active ingredients. An additional outcome of the project will be an extract library with a unprecedented level of associated spectroscopic information and metadata, to be used for future purposes. The high-caliber consortium brings together international leaders in small molecule natural products, bio-prospection, leading industries in agro-chemistry, cosmetics, and spectroscopic data management and analysis. Prime Contractor: University Athens (National and Kapodistrian Univ.); Athen; Graces/Hellas.
Global apiculture is facing an unprecedented crisis of increasing parasite pressure and a loss of hon-eybee biodiversity. SMARTBEES unites a team of experts with the necessary skills to build a bright and sustainable future. The SMARTBEES concept is low risk and high impact, using established protocols and state-of-the-art methods. Including world leading researchers from outwith the traditional honeybee sphere (e.g. acarology, genetic breeding and insect immunology). We will identify crucial facets of honeybee resistance to colony losses, Varroa and viruses. We will provide a step-change in the current mechanistic understanding of these traits, and will characterise the genetic background of the resistance mechanisms in honeybees. We will develop breeding strategies to increase the frequencies of these valuable traits in local honeybee populations, considering the variable need of both common and endangered subspecies and local beekeeping practises. Breeding efforts concentrating on very few races may endanger genetic diversity, to avoid this SMARTBEES will promote multiple local breeding efforts, to conserve local resilient populations and will develop molecular tools for describing and safeguarding future populations. SMARTBEES recognizes responsibility to protect our natural honeybee heritage. SMARTBEES will commission extension science, and work in cooperation with stakeholders to attain conservation by utilisation. SMARTBEES will establish a network of apiaries for performance testing, to encourage local uptake of resistant traits. These will be run mainly by beekeepers, thereby improving the local acceptability and dissemination, and support the long-term sustainability of the apicultural sector. SMARTBEES recognises the need to horizon scan for new threats, and the consortium includes the current EU reference laboratory to that end. SMARTBEES is an opportunity to make a lasting difference to the health, resilience and genetic diversity of our honeybees.
Project description: The project will analyse the costs, and thus the effectiveness of different organic standard setting procedures and certification systems as a basis for optimising of current EU certification system (Reg. EEC 2092/91). The central task is to quantify, for selected products, all relevant expenditure and transaction costs for certification along the entire supply chain for all actors involved: farm, processing, wholesaling, retail and import level as well as the administration level. Regarding the consumer side, it will be analysed how consumers perceive the various standards, logos and trademarks in the different regions of Europe. The project will make recommendations on how to increase the effectiveness and the efficiency of organic certification for the EU Commission, national competent authorities and private actors in organic food and farming. Main task of our department is the analysis of consumer recognition of different labels and their willingness to pay for different labels and underlying standards. Expected outcome: Efficient certification systems for organic farming with lower costs that will increase the competitiveness of the European organic farming sector.
EnviGuard is a response to the growing need for accurate real time monitoring of the seas/ocean and the aquaculture industries need for a reliable and cost-effective risk management tool. The implementation of the EnviGuard system will allow for early detection of harmful algae blooms (HAB), chemical contaminants, viruses and toxins thus preventing economic losses. The modular EnviGuard system will be made up of three different sensor modules (microalgae / pathogens, i.e. viruses & bacteria / toxins & chemicals), that are connected to the common interface 'EnviGuard Port' which collects and sends the information to a server. The data will be accessible through a website in real-time. The modularity of the system enables an individual setup for each purpose thus offering a tailor-made solution for each future client.
MariaBox will develop a wireless marine environment analysis device for monitoring chemical and biological pollutants while installed into a buoy, a maritime means of transport or a mooring. The device, based on novel biosensors, will be of high-sensitivity, portable and capable of repeating measurements over a long time, allowing permanent deployment at sea. The word 'MARIA' is the plural of the Latin 'mar' (sea) and expresses the wide applicability that this system offers in multiple locations where low-cost and real-time in situ analytical monitoring devices are required. The approach includes: a) a sensing and analysis box, b) a modular communication system, c) a flexible power system, d) a software platform, and e) a cell phone application. The box will transmit the collected data in real time through different channels according to local needs and geographical location: radio, GSM/GPRS/3G, WiFi, WiMAX or satellite link. The unit will be designed to be remotely controlled and will implement the OTA programming and OTA configuration features which will allow the user to update the firmware of the MariaBox unit and modify various configuration parameters wirelessly. Remote updates are a key factor in deployment scalability since it offers the only possibility of easily updating or reprogramming the devices after the initial deployment. Therefore, the maintenance costs are significantly reduced. Biosensors will be developed for 5 man-made chemicals and for 4 categories of microalgae toxins relevant to shell fish and fish farming. The novel biosensors will contribute to new standards for environmental analysis. The analytes selected for the biosensors are in line with 1) the Article 16 of the Water Framework Directive (2000/60/EC), 2) the Decision 2455/2001/EC and 3) The Commission Directive 2009/90/EC. The system developed will be demonstrated and validated in four different scenarios in selected locations in Norway, Spain, Cyprus and Ireland.
Das Projekt zielt darauf ab die genetischen Ressourcen von Leguminosen in Europa zu untersuchen um Ihre nachhaltige Produktion und Nutzung zu fördern. Neue Sorten und neue Lebens-und Futtermittel sollen die Proteinproduktion in der EU wettbewerbsfähiger und nachhaltiger machen. Kurzfristige Ziele S & T: 1. Bewertung lokaler genetischer Ressourcen von Erbse (Pisum sativum L.), Ackerbohne (Vicia faba L.) und Augenbohne (Vigna unguiculata (L.) Walp) für die Entwicklung von neuen Sorten für Lebens- und Futtermittel und die weitere Verwendung in der Zucht; 2. Entwicklung neuer Lebens- und Futtermittel aus verfügbaren europäischen Sorten von Erbse, Ackerbohne und Augenbohne; 3. Auswahl geeigneter Rhizobienstämme und arbuskulären Mykorrhizapilze zur Unterstützung der Stickstofffixierung und Entwicklung von neuen, kommerziellen Sporen-Impfstoffen; 4. Bewertung des Einflusses von Leguminosen auf die Bodeneigenschaften in nachhaltigen, regional-spezifischen Anbausystemen. Projektschwerpunkt an der BOKU sind die Wurzelsysteme.
BIOFECTOR is an integrated project with the aim to reduce input of mineral fertilisers in European agriculture by development of specifically adapted bio-effectors (BEs) to improve the efficiency of alternative fertilisation strategies, such as organic and low-input farming, use of fertilisers based on waste recycling products and fertiliser placement technologies. Bio-effectors addressed comprise fungal strains of Trichoderma, Penicillium and Sebacinales, as well as bacterial strains of Bacillus and Pseudomonades with well-characterized root growth promoting and nutrient-solubilising potential. Natural extraction products of seaweed, compost and plant extracts, as well as their purified active compounds with protective potential against biotic and abiotic stresses are also tested in various combinations. These features offer perspectives for a more efficient use of nutrients by strategic combination with the alternative fertilisation strategies. Maize, wheat and tomato are chosen as representative crops. Laboratory and European-wide field experiments assure product adaptation to the various geo-climatic conditions characteristic for European agriculture. The final goal is the development of viable alternatives to the conventional practice of mineral fertilisation as contribution to a more efficient management of the non-renewable resources of mineral nutrients, energy and water, to preserve soil fertility and to counteract the adverse environmental impact of agricultural production.
OPTIBIOCAT is a 48 months project aimed at developing biocatalysts based on feruloyl esterases (FAEs) and glucuronoyl esterases (GEs) for production of phenolic fatty- and sugar- esters with antioxidant activity for cosmetic industry, expanding the number/type of industrial biotransformations. Selected FAEs and GEs available within the consortium will be improved for their thermo- and solvent- resistance and substrate specificity by site-directed mutagenesis and directed evolution. Novel enzymes will be discovered by mining for new genes from available genomes. An inventory of novel FAEs and GEs will be developed including 50 fungal and 500 bacterial esterases, 25 site-directed and 20 directed evolved mutants. Enzymatic performances will be optimized to enhance the yield (up to the theoretical yield of 100%) and productivity (up to 0.5-1 g/l/h) of reactions giving the main targeted antioxidants: butyl ferulate, p-coumarate, caffeate, sinapate and 5-O-(trans-feruloyl)-arabinofuranose (using FAEs), glucuronate and benzyl glucuronate (using GEs). FAEs and GEs will be also tested for production of other compounds with improved biological activity and properties of hydrophilicity/hydrophobicity for cosmetic applications. Cost-effective methods will be developed for production of the new biocatalysts, in the g/L scale, and for their technical application to produce antioxidants for cosmetic industry, up to 20L. Enzyme immobilization will increase their recyclability up to ten cycles. The ability of the developed catalysts to work in conditions miming the industrial ones with reduced use of solvents and lower temperature than the chemical routes will be demonstrated. The techno-economic viability and environmental friendliness will be assessed considering a full industrial scale scenario. OPTIBIOCAT involves a highly skilled and multidisciplinary partnership of 16 partners from 8 EU countries, and it is a strongly industry driven project through the participation of 8 SMEs and 1 large company.
The project GRAIL has been build with 15 partners from 9 different countries with the aim of finalising the solutions given previously to the valorization of glycerol and transform then in valuable products in a biorefinery approach. The overall concept of GRAIL project is the use, exploitation and further development of the state of the art in the field of bio-based products from glycerol and the development research-driven cluster for the use of crude glycerol for the production of high-value platforms, as well as valued end products, harnessing the biotech processes. Therefore GRAIL project has a strong business focus and its ultimate goal is to set up implantation of biorefineries in close relationship with biodiesel. This project's aim is to develop a set of technologies for converting waste glycerol from biodiesel production in a biorefinery concept to end with products of high value such as 1,3 propanediol, Fatty acid glycerol formal esters, PolyHydroxyAlkanoates (PHA), Hydrogen and Ethanol, Synthetic coatings, powder coating resins, Secondary Glycerol Amine, Biobutanol, Trehalose, Cyanocobalamin (Vitamin B12), ß-carotene, Docosahexaenoic acid (DHA), .The GRAIL project has designed an overall strategy based on three main pillars covering all the value chain: Pillar 1: Raw materials: Evaluation of crude glycerol and purification - Pillar 2: Product development: Research and development to transform crude glycerol into other high added value such as biofuels, green chemicals and food supplements - Pillar 3: Industrial feasibility aspects including economic and environmental evaluation. This pillar will take the results of GRAIL from the product development to the industrial site. To carry out that the technical feasibility will be study on a pilot plant in a Demonstration (and the results will be important to evaluate the LCA and the economic feasibility (WP6).
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