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BIOFECTOR is an integrated project with the aim to reduce input of mineral fertilisers in European agriculture by development of specifically adapted bio-effectors (BEs) to improve the efficiency of alternative fertilisation strategies, such as organic and low-input farming, use of fertilisers based on waste recycling products and fertiliser placement technologies. Bio-effectors addressed comprise fungal strains of Trichoderma, Penicillium and Sebacinales, as well as bacterial strains of Bacillus and Pseudomonades with well-characterized root growth promoting and nutrient-solubilising potential. Natural extraction products of seaweed, compost and plant extracts, as well as their purified active compounds with protective potential against biotic and abiotic stresses are also tested in various combinations. These features offer perspectives for a more efficient use of nutrients by strategic combination with the alternative fertilisation strategies. Maize, wheat and tomato are chosen as representative crops. Laboratory and European-wide field experiments assure product adaptation to the various geo-climatic conditions characteristic for European agriculture. The final goal is the development of viable alternatives to the conventional practice of mineral fertilisation as contribution to a more efficient management of the non-renewable resources of mineral nutrients, energy and water, to preserve soil fertility and to counteract the adverse environmental impact of agricultural production.
OPTIBIOCAT is a 48 months project aimed at developing biocatalysts based on feruloyl esterases (FAEs) and glucuronoyl esterases (GEs) for production of phenolic fatty- and sugar- esters with antioxidant activity for cosmetic industry, expanding the number/type of industrial biotransformations. Selected FAEs and GEs available within the consortium will be improved for their thermo- and solvent- resistance and substrate specificity by site-directed mutagenesis and directed evolution. Novel enzymes will be discovered by mining for new genes from available genomes. An inventory of novel FAEs and GEs will be developed including 50 fungal and 500 bacterial esterases, 25 site-directed and 20 directed evolved mutants. Enzymatic performances will be optimized to enhance the yield (up to the theoretical yield of 100%) and productivity (up to 0.5-1 g/l/h) of reactions giving the main targeted antioxidants: butyl ferulate, p-coumarate, caffeate, sinapate and 5-O-(trans-feruloyl)-arabinofuranose (using FAEs), glucuronate and benzyl glucuronate (using GEs). FAEs and GEs will be also tested for production of other compounds with improved biological activity and properties of hydrophilicity/hydrophobicity for cosmetic applications. Cost-effective methods will be developed for production of the new biocatalysts, in the g/L scale, and for their technical application to produce antioxidants for cosmetic industry, up to 20L. Enzyme immobilization will increase their recyclability up to ten cycles. The ability of the developed catalysts to work in conditions miming the industrial ones with reduced use of solvents and lower temperature than the chemical routes will be demonstrated. The techno-economic viability and environmental friendliness will be assessed considering a full industrial scale scenario. OPTIBIOCAT involves a highly skilled and multidisciplinary partnership of 16 partners from 8 EU countries, and it is a strongly industry driven project through the participation of 8 SMEs and 1 large company.
The consortium will discover and carry to the stage of development candidates, plant derived small molecules with potential as new cosmetic and agrochemical agents. These compounds will derive from plants originating from major biodiversity hotspots in Europe, Africa, Latin America, and the Asia-Pacific region. The starting point of the project will be a diversity-oriented natural product library of 500 compounds from the existing compound repositories of three project partners. Screening of this compound library in assay panels for agrochemical (antifungal, herbicidal, insecticidal) and cosmetic properties (UV-protection, anti-aging, anti-hyper-pigmentation) will rapidly identify promising scaffolds. This knowledge will serve as entry points for a chemotaxonomy and chemo-diversity oriented collection of plants which are thought to contain structural variants and decorations of these scaffolds. A liquid library of 3600 extracts will be generated and screened. Stringent prioritization and profiling procedures will generate 300 compounds as focused sub-libraries around the privileged scaffolds. A state-of-the-art technology platform for miniaturized natural product discovery will be used for the purpose. Evaluation of these sub-libraries will lead to 30 compounds which will undergo advanced testing to qualify 5 compounds as development candidates for novel agrochemical and/or cosmetic agents with new or improved properties over existing active ingredients. An additional outcome of the project will be an extract library with a unprecedented level of associated spectroscopic information and metadata, to be used for future purposes. The high-caliber consortium brings together international leaders in small molecule natural products, bio-prospection, leading industries in agro-chemistry, cosmetics, and spectroscopic data management and analysis. Prime Contractor: University Athens (National and Kapodistrian Univ.); Athen; Graces/Hellas.
SYNPOL aims to propel the sustainable production of new biopolymers from feedstock. SYNPOL will theretoestablish a platform that integrates biopolymer production through modern processing technologies, withbacterial fermentation of syngas, and the pyrolysis of highly complex biowaste (e.g., municipal, commercial,sludge, agricultural). The R&D activities will focus on the integration of innovative physico-chemical, biochemical,downstream and synthetic technologies to produce a wide range of new biopolymers. The integration will engagenovel and mutually synergistic production methods as well as the assessment of the environmental benefitsand drawbacks. This integrative platform will be revolutionary in its implementation of novel microwave pyrolytictreatments together with systems-biology defined highly efficient and physiologically balanced recombinantbacteria. The latter will produce biopolymer building-blocks and polyhydroxyalkanoates that will serve tosynthesize novel bio-based plastic prototypes by chemical and enzymatic catalysis. Thus, the SYNPOL platformwill empower the treatment and recycling of complex biological and chemical wastes and raw materials in asingle integrated process. The knowledge generated through this innovative biotechnological approach will notonly benefit the environmental management of terrestrial wastes, but also reduce the harmful environmentalimpact of petrochemical plastics. This project offers a timely strategic action that will enable the EU to lead worldwide the syngas fermentation technology for waste revalorisation and sustainable biopolymer production.
GRACE pursues two key research objectives: Firstly, it aims to provide comprehensive reviews of the existing evidence on the health, environmental and socio-economic impacts of GM plants - considering both risks and possible benefits. GRACEs review strategy will go beyond what has been done before. Reviews will be conducted in a systematic, transparent and inclusive way based on procedures originally developed for evidence-based medicine (systematic reviews). The results will be made accessible to the public via an open access database and other channels. Secondly, GRACE will test various types of animal feeding trials and alternative methods without the use of animals in order to determine how suitable they are and what useful scientific information they provide for health risk assessments of GM food and feed. At present there are different views at the EU level and between Member States on the need for and scientific value of such studies. The project will also check whether extended feeding trials can improve risk assessments compared to in-vitro, in-silico and omics methods available today. Transparency and user and stakeholder involvement and scrutiny are key features of GRACE. The project will be working closely with representatives from a broad range of stakeholder organisations as well as with professional risk assessors and risk managers. This includes planning and preparing the research activities as well as discussing the results and drawing conclusions. For this purpose, the GRACE project will organise workshops and conduct interviews and surveys and prepare feed-back reports to ensure that the information and the views of stakeholders can feed into this project. IFZ is leading the work package for user and stakeholder involvement and will also work on the core review process.
Micro B3 will develop innovative bioinformatic approaches and a legal framework to make large-scale data on marine viral, bacteria; archaeal and protists genomes and metagenomes accessible for marine ecosystems biology and to define new targets for biotechnological applications. Micro B3 will build upon a highly interdisciplinary consortium of 32 academic and industrial partners comprising world-leading experts in bioinformatics, computer science, biology, ecology, oceanography, bioprospecting and biotechnology, as well as legal aspects. icro B3 is based on a strong user- and data basis from ongoing European sampling campaigns to long-term ecological research sites. For the first time a strong link between oceanographic and molecular microbial research will be established to integrate global marine data with research on microbial biodiversity and functions. The Micro B3 Information System will provide innovative open source software for data-processing, -integration, -visualisation, and -accessibility. Interoperability will be the key for seamless data transfer of sequence and contextual data to public repositories. Micro B3 will allow taking full advantage of current sequencing technologies to efficiently exploit large-scale sequence data in an environmental context. Micro B3 will create integrated knowledge to inform marine ecosystems biology and modelling. Moreover, it will facilitate detecting candidate genes to be explored by targeted laboratory experiments for biotechnology and for assigning potential functions to unknown genes. Micro B3 will develop clear IP agreements for the protection and sustainable use of pre-competitive microbial genetic resources and their exploitation in high potential commercial applications. To underline the translational character of Micro B3, outreach and training activities for diverse stakeholders are planned as well as an Ocean Sampling Day to transparently make project results accessible and gain valuable user feedback.
Die nachhaltige Produktion wichtiger Chemikalien, Lebensmittel- und Pharmazeutikakomponenten ist von hoher Bedeutung für die Gesellschaft und die Umwelt. Biotechnologische Produktionssysteme stellen eine sinnvolle Alternative zu den bisherigen, meist chemischen, Verfahren da. Die biotechnologische Produktionssysteme basieren jedoch bisher meist auf der Verwertung von Zuckern. Zucker, die aus Pflanzen gewonnen werden, benötigen kultivierbares Land, das mehr und mehr zur Gewinnung von Nahrungsmitteln benötigt wird. Methanol - mit einer weltweiten Produktionskapazität von mehr als 46 Millionen Tonnen pro Jahr - gilt als attraktiver alternativer Rohstoff für die biotechnologische Produktion von Spezial-, Fein- und Basischemikalien oder Kraftstoffen. Dies gilt insbesondere für den EU-Markt, wo die industrielle Biotechnologie noch durch strikte Preis- und Nutzungsregularien sowie Importlimitierungen von Agrargütern wie Mais oder Zucker behindert ist. Die Methanolversorgung kann sowohl auf fossilen, als auch auf erneuerbaren Ressourcen basieren, was es als flexiblen und nachhaltigen Rohstoff auszeichnet. In dem Projekt PROMYSE werden zum ersten Mal synthetisch-biologische Prinzipien für die Entwicklung von Zellfabriken angewendet um Methanol als generellen Rohstoff für die Produktion von Spezial- und Feinchemikalien verfügbar zu machen. Produktseitig liegt der Hauptfokus auf der Substanzklasse der Terpenoide.
PROMISE strives for multidimensional networking thus fostering integration. The primary strategic objective of PROMISE is to improve and increase the integration, collaboration and knowledge transfer between the new member states, old member states (EU15) and candidate countries through a collaborative workplan of exchange of expertise and regional training and dissemination actions, to tackle common food safety threats. PROMISE strives for sustainability through involvement of risk communicators. A further strategic objective is to integrate stakeholders like public health authorities and national food safety authorities from the old and new member countries in order to ensure the exploitation of research results into standardisation and harmonisation efforts. PROMISE will enhance the knowledge on pathogen transmission. While legal imports are well monitored for contamination and alerts are registered through the Rapid Alert System for Food and Feed RASFF notification systems, gates into the EU-27 could exist where food supply chains are not controllled. These uncontrolled imports present the risk that new strains of traditional pathogens will be transferred from third countries into the European Union. Analysing, assessing and interpreting this risk of introducing new strains of pathogens is one of the main objectives of PROMISE.
The Catch-C project assesses the farm-compatibility of Best Management Practices (BMPs) that aim to promote productivity, climate change mitigation, and soil quality. These are the three overall goals of sustainable soil management. Catch-C will first (WP2) set up a typology of the main farm types and agro-ecological zones across Europe. This frame, coupled to a pan-European database of socio-economic and biophysical data, will be used for spatially organising the information collected on current management; and for up-scaling the impacts expected from changes in management. Biophysical impacts of management practices will be assessed (WP3) primarily from a large set of current field experiments, executed by the participants. BMPs will be formulated, along with their trade-offs and synergies between productivity, climate change mitigation, and soil quality. Farmers, however, often do not adopt BMPs. Identifying the barriers against adoption, and formulating ways to remove these, are core activities of the project (WP4). Catch-C will survey farmer views on BMPs in all participant countries, assess costs and benefits of implementation, identify technical and ecological bottlenecks preventing adoption, develop a decision support tool, and prioritize innovation requirements to address bottlenecks. Policy measures can promote adoption in various ways, such as voluntary measures, regulation, and economic incentives. In interaction with policy makers, Catch-C will develop (WP5) guidelines for policies that will support the adoption of BMPs; and that are consistent with regional agro-ecological and farming contexts. Dissemination (WP6) includes scientific publication; discussing project results with farmers and policy makers; making information about BMPs and their adoption available to a wider audience; and stimulating awareness about the pros and cons of BMPs for different farm types and environments in participant countries.
The provision of public goods (including landscape services) in rural areas is recognized as one of the key topics for the future of agriculture and rural policy. Agriculture plays a major role in landscape management through its complex interlinkages with landscape features. In turn, the Common Agricultural Policy (CAP) remains an important driver of landscape management due to its importance as a determinant of farming activities in the EU. The main objective of the CLAIM project is to provide the knowledge base to support an effective CAP policy design in the direction of improved landscape management, particularly providing insights into the ability of landscape to contribute to the production of added value for society in rural areas. CLAIM is focused in particular on understanding and enhancing the contribution of landscapes management to socio-economic development and agricultural competitiveness in rural areas. This will be based on a pragmatic consideration of landscape services and their analysis through a mixed-method approach, taking into account the wider EU policy strategies (in particular related to innovation and the bioeconomy). The main expected result of the CLAIM project is an evidence-based policy support framework on the different and possible contributions of agriculture and the CAP to landscape management. The framework will be mainly developed and validated through a set of 9 case studies, a strong involvement of stakeholders at different territorial levels and a wide coverage of the perspectives of EU and candidate countries. The framework will finally take the practical form of a web-based manual to be implemented in accordance to stakeholders needs and indications.
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