This dataset is associated with the publication of Hefny, M., et al. (2020) A laboratory approach for the calibration of seismic data in the western part of the Swiss Molasse Basin: the case history of well Humilly-2 (France) in the Geneva area”. It includes data on mineralogical composition and experimental ultrasonic waves velocity measurements. It contains also seismic parameters calculated for the above-mentioned data. The measurements were performed as part of a database collection (SAPHYR) under the umbrella of the Swiss Commission of Geophysics (SGTK) and a project of the Canton of Geneva (GEothermie 2020), implemented by Services Industriels de Genève (SIG) for geothermal energy development (Moscariello 2019).