This dataset is a database of geochemical data, especially isotope analysis, for a selection of Roman denarii. The selection was primarily based on numismatic criteria. The focus is on denarii from the late Republic until the reign of Severus Alexander (220 CE) found in Germany. The data were collected as part of the first author's PhD thesis (T. Greifelt), with interpretation to follow in the completed thesis. A total of 213 denarii were sampled through several campaigns between 2017 and 19 from four collections including the LWL Museum für Kunst und Kultur Münster; the hoards from Hanau-Kesselstadt, Hanauer Geschichtsverein, Historisches Museum Hanau Schloss Philippsruhe; Regensburg-Kumpfmühl, Historisches Museum Regensburg; and coins from the Varusschlacht-Museum and Park Kalkriese. Sampling was carried out via drilling. The chemical preparation adhered to standard geochemical workflows adapted for archaeometric analysis. Analysis methods included EPMA and MC-ICP-MS. In this initial version of the publication, a data file with isotope results and detailed metadata is provided in .csv format. A subsequent version will include a second file with the elemental composition of the coins. The metadata profile of TerraLID (https://metadata.terralid.org/latest/pdf/TerraLID_Metadata_Profile.pdf ) was followed, which was specifically designed for applying (lead) isotope and elemental analysis to archaeological material. Geochemically obtained isotope and elemental data are used in archaeometallurgy to identify metal sources exploited in the production of ancient materials such as metal, glass, pigments, and others.