This dataset includes new geochemical and isotopic analyses for 46 samples from the Transminas and Pirenópolis dike swarms in southeastern and central Brazil. It comprises whole-rock major and trace element compositions, and Sr-Nd-Pb isotopes. The new analyses are presented for 46 samples using the bulk and in-situ data templates developed by EarthChem. Analytical work was conducted at the Geoanalítica Core Facility of the Instituto de Geociências, University of São Paulo, and at the Geochronology Laboratory of the University of Brasília, both in Brazil.