Das Projekt "Toxicite renale et transport tubulaire du cadmium chez le mammifere (FRA)" wird/wurde ausgeführt durch: Universite de Lausanne, Institut de Pharmacologie.Il s'agit d'un projet de recherche fondamentale, visant a caracteriser les sites d'absorption du cadmium dans le rein. Cet organe est le lieu principal d'accumulation du Cd dans l'organisme, lors d'exposition chronique. La caracterisation de ce(s) site(s) d'adsorption, a l'interieur du rein, implique l'utilisation de techniques de microponctions-microinjections tubulaires chez l'animal (rat) anesthesie. Par ailleurs, des techniques de mesure de la principale proteine induite lors d'exposition chronique au Cd (metallothioneine-Cd) sont developpees. Des investigations morphologiques (microscopie electronique) sont realisees en parallele, chez des animaux exposes au Cd. (FRA)
Das Projekt "FP4-MAST 3, Variability of Exchanges of the Northern Seas (VEINS)" wird/wurde gefördert durch: Kommission der Europäischen Gemeinschaften Brüssel / Stiftung Alfred-Wegener-Institut für Polar- und Meeresforschung e.V. (AWI). Es wird/wurde ausgeführt durch: Universität Hamburg, Zentrum für Meeres- und Klimaforschung, Institut für Meereskunde (IfM).General Information: The overall objective of the VEINS proposal reads: To measure and to model the variability of fluxes between the Arctic Ocean and the Atlantic Ocean with a view on implementing a longer term system of critical measurements needed to understand the high latitude oceans steering role in decadal climate variability. Exchanges between the North Atlantic and the Arctic Ocean result in the most dramatic water mass conversions in the World Ocean: Warm and saline Atlantic waters flowing through the Nordic Seas into the Arctic Ocean are separated by cooling and freezing into shallow fresh waters (and ice) and saline deep waters. The outflow from the Northern Seas to the south provides the initial driving of the global thermohaline circulation cell, the one to the north is of major impact to the large scale circulation of the Arctic Ocean Measuring these fluxes is a major requirement to quantify the turnover-rates within the large circulation cells of the Arctic and the Atlantic Oceans and a basic condition to understand the role of these ocean areas in climate variability on interannual to decadal scales. For this purpose a consortium of 18 institutions with long standing experience in high latitude observations and modelling propose to obtain 3 year synoptic time series of water and property transports in the key passages from the Arctic Ocean through the Nordic Seas into the Atlantic Ocean. These measurements will provide integral information on the water mass formation processes in the Northern Seas and on the forces driving the circulation between the different basins. This makes them especially suitable for the validation of large scale circulation models. Its results will be used to develop an efficient observational design to measure time series resolving up to decadal time scales, which are considered to be the most cirucial measurements for advancing our predictive capabilities for shorter term climate changes. Prime Contractor: Universität Hamburg, Zentrum für Meeres- und Klimaforschung, Institut für Meereskunde; Hamburg; Germany.
Das Projekt "Evaluation of occupational exposure to metallic mercury and of its early renal effects" wird/wurde ausgeführt durch: Universite de Lausanne, Institut de medecine du travail et d'hygiene industrielle.On a small group of workers exposed to relatively weak metallic mercury level, some variations of activity of urinary enzymes, of proteins concentration and of creatinine clearance have been displayed in relation with the level of exposure. Although the values are in the normal range the trend in the above mentionned parameters sign an early damage of the nephron. It should be stressed that this damage is presumably reversible. These results have to be confirmed on a larger scale.
Das Projekt "Nachweis von Quecksilber in den Organen von Feldhasen" wird/wurde ausgeführt durch: Universität Bern, Veterinär-Bakteriologisches Institut, Abteilung Geflügel-, Wild- und Fischkrankheiten.Ueber 2 1/2 Jahre wurden Feldhasenorgane von Tieren, die zur Sektion kamen, gesammelt und tiefgefroren - Bestimmung des Quecksilbers in Leber und Nieren mit Hilfe der flammenlosen Atomabsorptions-Spektrometrie - Vergleich der Befunde mit dem Sektionsbild und den Fundorten.