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Alternativmethoden - Einzelprojekt: CIRS-LAS - Berichtsystem kritischer Ereignisse in der Versuchstierkunde

Entwicklung eines Analyseverfahrens für Tenside aus Wasch- und Reinigungsmitteln und dessen praktische Anwendung auf Abwasserproben von Kläranlagenabläufen

Zur Bestimmung der Konzentrationen linearer Alkylbenzolsulfonate (LAS) und Alkylethersulfate (AES) in Kläranlagenabläufen wurden 7-Tagesmischproben (n=33) an Abläufe von 33 konventionellen Kläranlagen in Deutschland genommen. Zudem wurden an vier der untersuchten Kläranlagen die Zuläufe beprobt und ebenfalls auf LAS und AES untersucht, um Rückschlüsse auf die Entfernung dieser Tenside in konventionellen Kläranlagen ziehen zu können. Insgesamt umfasste die Studie die Analyse von vier LAS-Homologen (C10-C13) sowie von jeweils 10 Ethoxymeren zweier Homologe von AES (C12 und C14, jeweils mit 0-9 Ethoxygruppen). Die Probenvorbereitung bestand aus der Entfernung der wässrigen Phase mit Hilfe eines Rotations-Vakuum-Konzentrators und anschließender Resolvatisierung des Trockenrückstandes in einer definierten Menge Reinstwasser und Acetonitril. Die Identifikation und Quantifizierung der Zielanalyten erfolgte mittels Hochleistungsflüssigkeitschromatographie mit Tandem-Massenspektrometrie-Kopplung (HPLC-MS/MS). Die Leistungsfähigkeit der analytischen Methoden wurde in Leitungswasser und Kläranlagenablauf evaluiert. Die Analysemethoden zeigten für beide Matrices eine allgemein gute Richtigkeit sowie Präzision. Basierend auf den geschätzten mittleren Konzentrationen einzelner LAS-Homologe wurde eine mittlere Gesamtkonzentration von 14,4 Mikro g/L in Kläranlagenabläufen ermittelt. Verglichen mit LAS, wurden für AES stets geringere Gesamtkonzentrationen im Ablauf gemessen: Die mittlere AES-Gesamtkonzentration in den Abläufen betrug 0,57 Mikro g/L. Zwischen den Gesamtkonzentrationen von AES und LAS bestand keine Korrelation. In den Zuläufen beprobter Kläranlagen wurden im Mittel 3.200 Mikro g/L LAS detektiert. Damit betrug die mittlere Entfernung für LAS 99,6 %. Die mittlere AES-Konzentration im Kläranlagenzulauf belief sich auf 680 Mikro g/L, was einer mittleren AES-Entfernung von größer als 99.9% entspricht. Retrospektives Screening von 1.564 Tensiden und deren Transformationsprodukte (TPs) erfolgte durch ein zweites Labor unter Anwendung der Ultrahochleistungsflüssigkeitschromatographie mit Flugzeitmassenspektrometer-Kopplung (UHPLC-QTOF-MS). In vielen Fällen wurde die Konzentration von LAS von der Summe der Konzentrationen der Neben- und Transformationsprodukte von LAS überstiegen. Für die LAS-Nebenprodukte Dialkyltetralinsulfonate (DATS) lag die maximale Summenkonzentration bei 19 Mikro g/L, für die Sulfophenylalkylcarbonsäuren (SPACs) bei 17 Mikro g/L und für die Sulfotetralinalkylcarbonsäuren (STACs) bei 5,3 Mikro g/L. Hohe Konzentrationen von bis zu 7,4 Ìg/L wurden für Polyethylenoglycole in den Abwasserproben bestimmt. Die Gesamtkonzentration aller quantifizierten Tenside, TPs und Nebenprodukte in einer einzelnen Probe betrug bis zu 82 Mikro g/L.

Analysis of Pm3 resistance gene function in transgenic wheat

Can wheat be genetically engineered to become durably resistant to mildew? Individual resistance genes to mildew protect wheat plants against some, but not all, variants of this pathogen. A series of field trials will be carried out to test various means of genetically engineering wheat to enhance its resistance. The combination of several genes will play a central role in this project. Background Wheat has various genes that are responsible for resistance to mildew. One of these genes has seven variants, known as alleles. Individually, these alleles make wheat resistant to some, but not all, variants of the mildew fungus. There are in fact varieties of conventional wheat that have a certain degree of resistance to mildew. However, this resistance is often lost within a short time-frame. To overcome this shortcoming, genetic engineering will be used to combine the alleles. Field trials are the only way to find out whether long-term resistance can be achieved by this means. Objectives Various transgenic wheat lines will undergo comprehensive testing in a field trial (cf. Keller project I). The aim is first to establish whether the individual lines do indeed have better resistance to mildew. The second aim is to investigate how the additional gene affects the performance of the plant - in terms of yield, for example. The project also aims to analyse the effect of the environment on the plants' resistance properties. Methods Transgenic wheat lines - each containing one of the seven resistance alleles - will be developed and tested over three years for properties including seed maturation, yield and resistance following artificial and natural infection with mildew. Some of these lines will also be cultivated as a seed mixture. At the same time, wheat lines will be produced which combine the different alleles in the same plant. Both trials will test whether and to what extent mildew develops less frequently. Significance This is the first time that a field trial of this size will be carried out with transgenic plants in Switzerland. The project will not only elicit a major response from the general public, it will also provide new facts about the possible benefits of genetically modified plants.

Forest management and habitat structure - influences on the network of song birds, vectors and blood parasites

Forest structure is altered by humans for long times (Bramanti et al. 2009). The long lasting modification of forests pursuant to human demands modified the living conditions for birds as well as for many other animals. This included changes in resource availability (e.g., food, foraging, nesting sites) and changes of interspecific interactions, e.g., parasitism and predation (Knoke et al. 2009; Ellis et al. 2012). Also species compositions and the survivability of populations and even species are affected. The loss of foraging sites and suitable places for reproduction, the limitation of mobility due to fragmented habitats and the disturbances by humans itself may lead to more stressed individuals and less optimal living conditions. In certain cases species are not able to deal with the modified requirements and their populations will shrink and even vanish. Depending on the intensity of management and the remaining forest structure, biodiversity is more or less endangered. Especially in systems of two or more strongly connected taxa changing conditions that affect at least one part may subsequently affect the other, too. One system of interspecific communities that recently attracted the attention of biologists includes birds, blood parasites (haemosporidians) and their transmitting vectors. For instance, avian malaria (Plasmodium relictum) represents the reason for extreme declines in the avifauna of Hawaii since the introduction of respective vectors (e.g. Culicidae) during the 20th century (van Riper et al. 1986, Woodworth et al. 2005). With the current knowledge of this topic we are not able to predict if such incidences could also occur in Germany. All in all, different management strategies and intensity of forest management may influence the network of birds, vectors and blood parasites and change biodiversity. To elucidate this ecological complex, and to understand the interactions of the triad of songbirds as vertebrate hosts, dipteran vectors and haemosporidians within changing local conditions, I intend to collect data on the three taxa in differently managed forest areas, the given forest structure and the climatic conditions. I will try to explain the role of abiotic factors on infection dynamics, in detail the role of forest management intensity. Data acquisition takes place at three spatially divided locations: inside the Biodiversity Exploratory Schwäbische Alb, at the Mooswald in Freiburg, and inside the Schwarzwald.

Flüchtlingsunterkünfte in Hamburg - Portal Hamburg

Die Karte gibt einen Überblick über bestehende und geplante Flüchtlingsunterkünfte in Hamburg.

Human dimensions and urban landscape development - A case study in Suzhou, China

Humanity has influenced and changed the large majority of the earths landscapes, especially those in urban areas. There is no doubt that it is crucial to include human dimensions - perceptions, attitudes, preferences etc. - in terms of landscape inheritance, conservation, development and management or what. Public perception and preference research has a long lasting history in landscape subjects, and has been playing an important role in practical implementation. This study will be conducted in Suzhou, China - a typical Chinese city with numerous ancient cultural heritages and facing endless modernization and urbanization. Literate review will be thoroughly carried out on respect to the processes, states, significances of human dimensions for landscapes. The interpretation of historical materials about landscape changes during decades of the research site will be completed. The targeted objects will be the residents there and visitors. There are still more than 200.000 permanent residents living in the research core, who represent the main force of conserving the ancient heritages lasted thousands years. Therefore, their attitudes towards the landscape changes, ancient landscape elements or symbols are vital, and should be included in routines for landscape design, management and conservation. Moreover, up to millions of visitors from both inside and outside of China come to Suzhou every year, which makes the study concerning their perceptions and preferences even more critical. The well-structured questionnaires, together with semi-open or open interviews will be applied aimed at different targeted groups, and the results will be interpreted and evaluated based on scientific theories and methodologies in both quantitative and qualitative ways. Eventually, how these findings could be used to inform the landscape policy-makers, designer, planner or managers and how to transfer the results into practical status in other cities of China or even in other developing countries facing the same dilemmas would be generated.

High Performance, Economical and Sustainable Biocomposite Building Materials

The aim of BioBuild is to use biocomposites to reduce the embodied energy in building facade, supporting structure and internal partition systems by at least 50Prozent over current materials with no increase in cost. This will lead to a step change in the use of sustainable, low carbon construction materials, by replacing aluminium, steel, FRP, brick and concrete in buildings. Facades are widely used in construction, primarily to protect and insulate the internal structure. Internal partitions are used to divide space, carry utilities and provide thermal and acoustic insulation. The current materials used such as aluminium, steel, brick and concrete are energy intensive to produce and have high embodied energy. FRP is an alternative construction material, benefitting from low weight, formability and simple manufacturing, allowing low material content structures and innovative design. However, typical resin and glass fibre are non-renewable, energy intensive to synthesise. Biocomposites overcome these drawbacks, whilst maintaining the benefits, being based on natural fibres and bioresins which have low embodied energy and cost. Biocomposites are renewable and sustainable resin and reinforcement structures. The resins in this project are furan and cashew nut oil based with reinforcing fibres of flax and jute. Bast fibres have lower environmental impacts than glass, concerning climate change and energy but have similar properties. Biocomposites are used commercially in automotive interior parts, but for outdoor applications they can degrade due to moisture absorption and bio-degradation. BioBuild will develop biocomposites and construction products with a life span of 40 years, by protecting the fibres with novel treatments and coatings. The result of the project will be a low cost, lightweight, durable and sustainable biocomposite building system, with full technical and environmental validation, offering low embodied energy construction materials.

A pan-European infrastructure for quality in nanomaterials safety testing (QNANO)

Objective: Nano-scale objects interact with living organisms in a fundamentally new manner, ensuring that a fruitful marriage of nanotechnology and biology will long outlast short term imperatives. Therefore, investment in an infrastructure to drive scientific knowledge of the highest quality will have both immediate benefits of supporting the safety assessment of legacy nano-materials, as well as pointing towards future (safe) applications with the lasting benefits to society. There are immediate priorities, for few doubt that serious damage to confidence in nanotechnology, unless averted, could result in missed opportunities to benefit society for a generation, or more. QNano will materially affect the outcome, at this pivotal moment of nanotechnology implementation. The overall vision of QNano is the creation of a 'neutral' scientific & technical space in which all stakeholder groups can engage, develop, and share scientific best practice in the field. Initially it will harness resources from across Europe and develop efficient, transparent and effective processes. Thereby it will enable provision of services to its Users, and the broader community, all in the context of a best-practice ethos. This will encourage evidence-based dialogue to prosper between all stakeholders. However, QNano will also pro-actively seek to drive, develop and promote the highest quality research and practices via its JRA, NA and TA functions, with a global perspective and mode of implementation. QNano will also look to the future, beyond the current issues, and promote the growth and development of the science of nano-scale interactions with living organisms. By working with new and emerging scientific research communities from medicine, biology, energy, materials and others, it will seek to forge new directions leading to new (safe, responsible, economically viable) technologies for the benefit of European society.

Balanced European Conservation Approach (BECA) - ICT services for resource saving in social housing

The BECA (Balanced European Conservation Approach - ICT services for resource saving in social housing) project addresses the need to reduce energy consumption in European social housing by a very significant amount to meet overall emission reduction targets. To substantially reduce peak and overall demand for energy and water across EU social housing, BECA will develop a full set of innovative services for resource use awareness and resource management. Balance is achieved by addressing not only energy but water, by including all key energy forms - electricity, gas and heating - and by including strong activities in Eastern Europe as well as in the North, South and West of the EU. Social housing organisations in 7 European countries (Germany, Italy, Spain, Sweden, Bulgaria, Czech Republic, Serbia) and their partners are cooperating in the project to provide ICT-based energy management and energy awareness services directly to social housing tenants and service operators. Services will be piloted by approx. 5,000 social housing tenants across 7 sites in 7 European countries. Sustained reductions in resource use are to be achieved through usable ICT-based services directly to tenants, as well as by effective monitoring and control of local power generation and, for district heating, the full heat delivery chain. Intensive work will be addressed to optimising services for tenants and maximising impact on resource use behaviour. Service requirements will be investigated with tenants and staff and service prototypes based on initial use cases will be subject to user testing within the first year of the project. Results are used to finalise service design in a second iteration of use case definition and service specification lasting some 8 months, cumulating in implementation of operational services at all the 7 pilot sites. Pilots at sites will operate for at least 14 months; lead sites will be identified to being operation early and provide example solutions to others. The consortium, led by social housing providers and public authorities includes global ICT and service providers and distribution network operators working with local consultants and specialist advisors to carry out all steps in service implementation.

Assessing Global Land Use and Soil Management for Sustainable Resource Policies (Land and Soils)

The Land and Soils Working Group of the International Resource Panel is preparing a comprehensive review of the challenges and opportunities facing land and soil management from the local to global level. Global land use and soil management are both connected and complementary aspects of agriculture, forestry and built-up land development with consequences on food, energy, material and water security. Global land use change is currently characterised by the expansion of agricultural land and built-up areas along with land degradation and the polices which support these processes. Expansion is taking place at the expense of global forests, savannahs and grasslands while degradation is the result of soil erosion, nutrient depletion, water scarcity, salinity and the disruption of biological cycles, putting the best quality soils of the world under risk. As world dietary habits change, international trade and a rising consumption of goods are fuelling the demand for land. Globalisation is increasing the distance between production and consumption, so that consumer decisions to buy products and the detrimental impacts which may be associated with those products are drifting apart. The result is an increasing competition for land with unintended and unrecognised side-effects. Policy is therefore challenged to follow a double approach: tackling both the field level of sustainable extraction and the global level of sustainable use. This project explores the connections, trade-offs, and relationships between land use, soil management and resource security more deeply. It proposes developing a safe operating space for global land use and safe operating practices for soil management that could work together towards ensuring a long-lasting and sustainable supply of products for food, feed, fuel and materials.

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