Evidence is compelling for a positive correlation between urbanisation and increment of allergic sensitisation and diseases. The reason for this association is not clear to date. Some data point to a pro-allergic effect of anthropogenic factors on susceptible individuals. Data analysing the impact of environmental - natural and anthropogenic - factors on the allergenicity of allergen carriers such as pollen grains are scarce, and if applicable only taken from in vitro experimental designs. This study will analyse one of the most common allergy inducers in northern Europe - the birch pollen. Under natural exposure conditions, birch pollen will be analysed with respect to their allergenicity. Within an interdisciplinary research team this study will evaluate the effect of natural (e.g. soil, climate, genetic background) and anthropogenic (e.g. traffic pollutants) factors on birch pollen in a holistic approach including analysis of allergen bioavailability, release of pollen associated lipid mediators from birch pollen grains, in vitro immunostimulatory activity and in vivo allergenic potential. These data collected in the time course of three years will significantly add to our understanding how urbanisation and climate change influence the allergenicity of birch pollen and will help us in the future to set up primary prevention studies.
Pilze sind eine der am diversesten, jedoch am wenigsten untersuchten mikrobiellen Gruppen in marinen Gewässern. Eine Untergruppe der Pilze, kurz als Chytridien bekannt, umfasst häufig auftretende Parasiten auf Phytoplankton, welche eine starke Belastung für das Phytoplanktonwachstum, die Entwicklung von Algenblüten und deren Populationsdynamiken darstellen. Parasitäre Chytridien befallen alle Hauptgruppen von Phytoplankton und treten bevorzugt in Küstenregionen mit hoher Phytoplanktonbiomasse und Produktivität auf. Die Auswirkungen von parasitären Pilzen auf Stoffkreisläufe und die Funktion von Ökosystemen sind jedoch kaum bekannt bzw. quantifiziert. Die Emmy Noether-Nachwuchsgruppe wird die funktionelle und quantitative Rolle parasitärer Pilze für die Phytoplanktonproduktivität und den Stoffkreislauf in Brack- und Meerwasser untersuchen. Unsere Ziele sind (1) Betrachtung der Wechselwirkungen zwischen Phytoplankton und Chytridien auf Einzelzell-Ebene, (2) Untersuchungen der integrativen Rolle von Chytridien in aquatischen Nahrungsnetzen und (3) Aufklärung der Auswirkungen von parasitären Pilzen auf Remineralisierungs- und Sedimentationsprozesse. Unser umfassender Ansatz beinhaltet experimentelle Studien mit Phytoplanktonâ€ÌPilz Co-Kulturen sowie mit natürlichen Planktongemeinschaften, mittels Analysen auf Zell- und Mikoskalen-Ebene bis hin zu mesoskaligen Stoffflüssen entlang der Wassersäule. Im Wesentlichen werden wir den Transfer von Kohlenstoff und Stickstoff vom Phytoplankton durch das pelagische Nahrungsnetz innerhalb der photischen Zone bis hin zum Absinken als Detritus in die Tiefe verfolgen. Das Projektergebnis soll ein ganzheitliches Verständnis der Rolle von Chytridien an der Basis aquatischer Nahrungsnetze und Produktivität fördern, einschließlich der zugrunde liegenden Mechanismen und Größenordnungen. Angesichts der potenziellen Signifikanz parasitärer Pilze für die Abschwächung von Produktivität, Sinkstoffflüssen aber auch von toxischen Algenblüten in Küstengebieten, sollen die gewonnenen Daten mit lokalen und globalen Stoffkreisläufen verknüpft und in zukünftige Entscheidungen zum Küstenmanagement implementiert werden.
In order to understand the interlinked problems in the Nexus (Latin = connection, linkage, interrelation) of water, energy and food security, close cooperation between scientists and practitioners from different fields is necessary. The present and future challenge of a reliable supply with water, energy and food is an example, where isolated considerations do not lead to viable solutions. Sustainable action and meaningful research in these highly interconnected fields require a holistic and comprehensive perspective and a new approach. In this sense, a collaborative research structure with a holistic view on the Nexus of Water, Energy and Food security was established in 2013 at the Cologne University of Applied Sciences. The project bundles some of the research efforts of 11 professors from different faculties and institutes. The researchers jointly work on initiating new cooperation projects with partners from industry, academia and civil society. Together they aim at exploring new technologies and applying new approaches to solve major issues of efficiency and sustainability in resource use.
The final goal of the EUROWET project is to integrate the substantial multidisciplinary European research in wetlands to help attain the sustainable management of the water cycle. This will be achieved by the translation of state-of-the art science developed at both national and European levels, into practical guidance for end-users. This will be achieved by a comprehensive review, expert assessment and a focussed dissemination strategy. There is considerable scientific knowledge and technical experience gained in diverse aspects of wetland science and management including hydrology, biogeochemistry, ecology restoration, socio-economic and policy analysis. However the results of research and management experience are still too fragmentary and not sufficiently orientated to problem-solving or simply inadequately framed to be effectively transferred to, or used by, stakeholders and policy-makers. Simultaneously the general outcome of the scientific research has been increased awareness of the significance of wetlands in delivering goods and services important for human welfare including quality of life, biodiversity conservation and maintenance or enhancement of environment quality. Despite this wetlands continue to be degraded and lost throughout Europe without adequate consideration of the wider benefits to be achieved from this management. The new Water Framework Directive (WFD) promotes a unique opportunity to redress this problem by means of the holistic, integrated approach to water management. There is currently in preparation horizontal guidance on Wetlands as part of the Common Implementation Strategy (CIS) process. There is however work still to be done on providing more specific scientific and technical guidance on the effective implementation of the Directive with respect to wetlands. This is particularly the case in relation to Integrated River Management, the CIS cluster within which wetlands are being considered in the WFD.
In pedology, soilscapes are characterised by a typical spatial and taxonomic relation between the soils, as well as by the relation between the soils and other landform and landscape characteristics. These landscape characteristics as driving forces for soil formation show local, regional and supra-regional components. It is therefore important to gather and incorporate information about the soil forming factors not only from a specific sampling point, but also from its larger spatial surroundings for reasonable descriptions of the complex soil-landscape relations. Therefore, multi- or hyper-scale approaches are required, which however, are rarely reported in literature. Moreover, most studies are lacking any interpretations and concepts for the description of soil formation, although these are most crucial for describing and understanding the complex environmental processes and interactions of landscapes and soils.The aim of this project is to develop a new hyper-scale mapping approach as well as a new theoretical concept for its pedologic interpretation. Under the overarching goal of a new spatially contextualized soil formation theory the objective of the project is to achieve more holistic descriptions of soil and environmental formation but also the optimization of spatial prediction models for estimating soil properties functions and threats. This is urgently needed in order to meet the increasing global demand for accurate and high-resolution soil information to estimate and handle the impacts of global climate change, population growth, food security, and bio energy.The framework, which will be developed, applied, tested and validated for several landscapes around the world in this project, focuses on determining the influence of local, regional and supra-regional landscape surface shape on soil formation in terms of hyper-scale digital terrain analysis and tries to reveal the interactions of relief with other environmental covariates on different spatial scales. The objectives are (i) to develop a new hyper-scale terrain analysis method, (ii) to apply, develop and/or adapt specific data analysis and data mining approaches to derive the information required for pedological interpretations and as an integrative part (iii) to develop a new theoretical framework for soil formation analysis. This will provide a) information on the specific influence of local to supra-regional parts of environmental covariates on soil formation, b) approaches to visualize the geomorphic systems interacting with other covariates and jointly influence soil formation, c) approaches to derive information on the interactions between different geomorphic features and scales, as well as d) information on the complex interactions between geomorphic and other environmental covariates at different scales to derive better knowledge about the spatial distribution as well as the genesis of one of our most important environmental resources - soil.
The aim of the LORRY project is to reduce trucks carbon footprint by developing an innovative low rolling Resistance tyre concept combined with a comprehensive tool box for fleet fuel saving management. This proposed concept will go beyond current state of art and stakeholder or market expectations regarding tyre rolling resistance, mileage, driving safety, driving performance and material and manufacturing sustainability. Steer and trailer tyres developed in the framework of the project will demonstrate a minimum 20Prozent gain in truck tyre rolling resistance. Truck tyre wear and wet safety performance levels will be improved additionally. To reach this objective, a multidisciplinary consortium (7 public / 4 private partners) has been created covering the fields of tyre technology, rubber and filler technology, nanotechnologies, composite physics, sensory, transport and road infrastructure. A complete set of complementary scientific evaluation methods will enable the understanding of interactions between new tread pattern design and new material composites as well as the tyre performance dependency on tyre-vehicle Operation and road conditions. LORRY consists in a holistic approach for an intelligent surface transport system. New tyre and truck fleet operating concepts resulting from the programmed will go beyond European Green Car Initiative roadmap expectations for 2015 and smoothly bridge and feed next coming tailored trucks and sustainable trucks initiatives, forecasted respectively for 2020 and 2025.
Wood2CHem: A computer-aided platform for developing bio-refinery concepts The bio-refinery concept offers the timber industry numerous development opportunities by integrating the production of value-added products made from biomass. The computer-aided platform Wood2CHem, developed within the scope of this project, will help to devise innovative means for promoting wood as a resource using a holistic and integrated approach. Background Due to its composition and complex chemical structure, wood can be used to make a large number of value-added products. The bio-refinery concept proposes to widen the range of products derived from wood while adopting a systemic approach aimed at promoting synergies in the production of various products by integrating different processes. It therefore offers an enormous development potential for the wood sector and opens up many new markets. The development of bio-refinery concepts poses a significant challenge. A large number of processes that integrate studies and technologies of innovative transformation need to be evaluated, integrated and optimised using a holistic approach before the most promising concepts can be identified. Aim By applying techniques from process engineering, energy integration and multi-objective optimisation, the consortium of the Wood2CHem project proposes to develop a computer-aided platform for systematically generating the most promising bio-refinery models and evaluating their thermodynamic, economic and environmental performance. This integrated platform will be developed by combining expertise in chemical engineering and process engineering. It is aimed at integrating technological developments of wood transformation and will be validated in industrial case studies. Significance The Wood2CHem project concerns the development of industrial concepts and will therefore primarily interest experts and engineers in the field who wish to develop integrated and innovative concepts for a rational promotion of wood. It will allow them to envisage and compare inegrated process chains. The platform will integrate all the actors wishing to assume the perspective of industrial ecology.
The major aim of CARCINOGENOMICS is to develop in vitro methods for assessing the carcinogenic potential of compounds, as an alternative to current rodent bioassays for genotoxicity and carcinogenicity. The major goal is to develop a battery of mechanism-based in vitro tests accounting for various modes of carcinogenic action. These tests will be designed to cover major target organs for carcinogenic action e.g. the liver, the lung, and the kidney. The novel assays will be based on the application of 'omics' technologies (i.e. genome-wide transcriptomics as well as metabonomics) to robust in vitro systems (rat/human), thereby also exploring stem cell technology, to generate 'omic' responses from a well-defined set of model compounds causing genotoxicity and carcinogenicity. Phenotypic markers for genotoxic and carcinogenic events will be assessed for the purpose of anchoring gene expression modulations, metabolic profiles and mechanism pathways. Through extensive biostatistics, literature mining, and analysis of molecular-expression datasets, differential genetic pathways will be identified capable of predicting mechanisms of chemical carcinogenesis in vivo. Furthermore, generated transcriptomic and metabonomic data will be integrated into a holistic understanding of systems biology, and applied to build an iterative in silico model of chemical carcinogenesis. Subsequently, predictive gene expression profiles, typically consisting of some 150-250 genes, will be loaded onto high throughput dedicated DNA-chips, thus accelerating the analysis of transcriptomic responses by a factor of 100. It is expected that the outcome of this project will generate a platform enabling the investigation of large numbers of compounds for their genotoxic and carcinogenic potential, as envisaged under the REACH initiative. This will contribute to speeding the identification of potential harmful substances to man, while lowering costs and reducing animal tests. Prime Contractor: Maastricht, University, Health Risk Analysis and Toxicology (Grat); Maastricht, Nederland.
Vor dem Hintergrund des starken Wachstums afrikanischer Großstädte und damit zusammenhängender Versorgungs- und Umweltprobleme gewinnt die sich dort besonders stark entwickelnde urbane und peri-urbane Landwirtschaft zunehmend an wissenschaftlichem Interesse. Im Gegensatz zu den auf äußerst nährstoffarmen, erosionsgefährdeten Böden des Hinterlandes vorherrschenden subsistenzorientierten Landnutzungssystemen ist die UPL durch hohe Inputintensitäten gekennzeichnet. Allerdings gibt es derzeit kaum grundlagenorientierte Untersuchungen zu Produktivität, Stoffumsätzen und umweltrelevanten Externalitäten der UPL, die tierische und pflanzenbauliche Produktionssysteme vereint. In diesen Forschungsprojekt sollen am Beispiel der nigrischen Hauptstadt Niamey Stoffflüsse in der UPL in exemplarisch ausgewählten Haushalten gemessen und in ihren wesentlichen Kenngrößen modelliert werden. Diese Untersuchungen werden anschließend zur Prüfung von Vorschlägen zur Steigerung der Ressourceneffizienz herangezogen. Zu diesem Zweck werden in einem ersten Schritt in 20 nach dem Grad ihrer Integration von Tierhaltung und Ackerbau ausgewählten Beispielbetrieben die horizontalen Einträge und Verluste von Stickstoff (N), Phosphor (p) und Kalium (k) an den Schnittstellen Boden-Pflanze-Tier im Jahresverlauf erfasst. Auf einigen dieser Betriebe sollen zu repräsentativen Zeitpunkten atmosphärische Emissionen (Denitrifikations- und Ammoniakverluste) mit einem photoakustischen Spurenglasanalysator ermittelt und sickerungsbedingte Nährstoffverluste (N, P, und K) durch den Einbau von Si-Carbid-Saugplatten gemessen werden. In einem zweiten Schritt wird der Einfluss gezielter Verbesserungsmaßnahmen im Stoffmanagement (Einsatz einer Einstreu von Stroh und Rohphosphat in der stationären Haltung von Tieren, kontrollierte Kompostierung des Tierdungs) auf die atmosphärischen N-Verluste und Dungqualität geprüft. Im dritten Schritt soll der Einfluss verschiedener Intensitäts- und Integrationsstufen der UPL auf die erfassten Stoffflüsse im Kontinuum Boden-Pflanze-Tier-Umwelt mittels eines bio-physikalischen Models abgebildet werden.
A sustainable and efficient freight transport in Europe plays a vital role in having a successful and competitive economy. Freight transport is expected to grow by some 50 % (in tonne-kilometres) by 2020. However rail has, in many areas, been displaced from a dominant position as road transport services have grown and developed in capability and levels of sophistication that have not been matched by rail service providers. SUSTRAIL aims to contribute to the rail freight system to allow it to regain position and market and the proposed solution is based on a combined improvement in both freight vehicle and track components in a holistic approach aimed at achieving a higher reliability and increased performance of the rail freight system as a whole and profitability for all the stakeholders. The SUSTRAIL integrated approach is based on innovations in rolling stock and freight vehicles (with a targeted increased in speed and axle-load) combined with innovations in the track components (for higher reliability and reduced maintenance), whose benefits to freight and passenger users (since mixed routes are considered) are quantified through the development of an appropriate business case with estimation of cost savings on a life cycle basis. In fact, a holistic approach to vehicle and track sustainability has to be taken, since improvements in track design and materials alone are not enough as demands on the rail system increase. Contributions from the different topic areas (vehicles, track, operations) will be demonstrated on real routes, offering geographic dispersion as well as differences in type, speed, and frequency of traffic. A strong multidisciplinary consortium committed to concrete actions aligned toward a common outcome has been grouped for the achievement of the challenging objectives of the project with a balanced combination of Infrastructure managers, freight operators and Industry, including Large and Small enterprises, with support from Academia.
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