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Optimized Strategies for Risk Assessment of Chemicals based on Intelligent Testing (OSIRIS)

The proposed regulation concerning the registration, evaluation, authorisation and restriction of chemicals (REACH) requires demonstration of the safe manufacture of chemicals and their safe use throughout the supply chain. There is therefore a strong need to strengthen and advance human and environmental risk assessment knowledge and practices with regard to chemicals, in accord with the precautionary principle. The goal of the project OSIRIS is to develop integrated testing strategies (ITS) fit for REACH that enable to significantly increase the use of non-testing information for regulatory decision making, and thus minimise the need for animal testing. To this end, operational procedures will be developed, tested and disseminated that guide a transparent and scientifically sound evaluation of chemical substances in a risk-driven, context-specific and substance-tailored (RCS) manner. The envisaged decision theory framework includes alternative methods such as chemical and biological read-across, in vitro results, in vivo information on analogues, qualitative and quantitative structure-activity relationships, thresholds of toxicological concern and exposure-based waiving, and takes into account cost-benefit analyses as well as societal risk perception. It is based on the new REACH paradigm to move away from extensive standard testing to a more intelligent, substance-tailored approach. The work will be organised in five interlinked research pillars (chemical domain, biological domain, exposure, integration strategies and tools, case studies), with a particular focus on more complex, long-term and high-cost endpoints. Case studies will demonstrate the feasibility and effectiveness of the new ITS methodologies, and provide guidance in concrete form. To ensure optimal uptake of the results obtained in this project, end-users in industry and regulatory authorities will be closely involved in monitoring and in providing specific technical contributions to this project.

Driving under the influence of drugs, alcohol and medicine (DRUID)

Objective: As consumption of psychoactive substances such as alcohol, drugs and certain medicines are likely to endanger the drivers aptitude and impaired driving is still one of the major causes for road accidents, some active steps have to be taken to reach the goal of a 50% reduction in the number of road deaths in the EU. The objective of DRUID is to give scientific support to the EU transport policy to reach the 2010th road safety target by establishing guidelines and measures to combat impaired driving. DRUID will - conduct reference studies of the impact on fitness to drive for alcohol, illicit drugs and medicines and give new insights to the real degree of impairment caused by psychoactive drugs and their actual impact on road safety - generate recommendations for the definition of analytical and risk thresholds - analyse the prevalence of drugs and medicines in accidents and in general driving, set up a comprehensive and efficient epidemiological database.

Hydrogen for clean urban transport in Europe (HyFleet:CUTE)

The HyFLEET:CUTE project involves the operation of 47 hydrogen powered buses in regular public transport service in 10 cities on three continents. The Project aims to diversify and reduce energy consumption in the transport system by developing new, fuel efficient hydrogen powered bus technology, and clean, efficient and safe ways of producing and distributing hydrogen fuel. Objectives: - Develop hydrogen powered bus technology in order to reduce the consumption of fuel and energy in the whole transportation system. - Develop efficient and environmentally 'friendly' ways to produce hydrogen. - Research the technology and development needs to establish a hydrogen refueling infrastructure. - Inform the community and key decision-makers about the potential advantages of a hydrogen-based transport system and how they can help to develop it.

Compact direct (m)ethanol fuel cell for portable application (MOREPOWER)

Objective: The objective is to develop a low-cost, low temperature, portable direct methanol fuel cell device. It will also offer limited operation on ethanol fuel and will be of compact construction and modular design. The development will include novel proton exchange membranes, anode and cathode electro catalysts and fully optimised multilayer membrane electrode assemblies. New low-cost proton exchange membranes will be developed to reduce the methanol crossover rate through the electrolyte to levels significantly lower than that of currently available materials (e.g. Nafion). New electro catalyst materials will be developed to enhance the low temperature methanol (and ethanol) electro-oxidation activity of the anode. Catalyst development for the cathode will focus on enhancing the oxygen reduction activity of platinum electro catalyst and increasing its selectivity to enhance methanol tolerance. The structure of the electro catalyst and electrode layers will be optimised to promote efficient operation at low temperatures with practical flows and pressures. System optimisation, simplification and miniaturization will be carried out. The final performance objectives will be: single cells operating at 0.5V / cell at 0.2 Acm-2 at 30-60 C (in atmospheric pressure air). Prototypes of 100 and later 500 W stacks, operating at low temperatures with aimed electrical characteristics of 40 A/12.5 V, will be the targets of the project. The effective operation at this low temperature is particularly challenging. Additionally a conceptual study for up-scale will be supplied. A narrow collaboration between research centres and industry will make possible a rapid exploitation of the new components and system developments. A SME will be responsible for the integration and will deliver the prototypes. The potential market for portable fuel cells includes weather stations, medical devices, signal units, auxiliary power units, gas sensors and security cameras.

Expressed Sequence Tags (ESTS) of Toxic Algae (ESTTAL)

Harmful algal blooms (HABs) are caused by local proliferation of algae, with deleterious consequences, particularly in coastal waters throughout the world. Negative environmental effects include toxicity to human consumers of seafood, marine faunal mortalities or morbidity, habitat damage, disruption of marine food webs and economic losses to fishing, aquaculture, and tourism. In Europe, socio-economic factors and human health risk have led to comprehensive surveillance programmes for harmful microalgae and their toxins. Among harmful microalgae and cyanobacteria in European marine and brackish waters, many produce potent neurotoxins, ichthyotoxins or hepatotoxins. Although structural elucidation of many of these groups of toxins has advanced, much less is known about biosynthetic pathways and gene regulation in toxigenic species. We propose a limited genomic study of expressed sequence tags (ESTs) for toxigenic representatives of major eukaryotic microalgal groups, including dinoflagellates, raphidophytes, prymnesiophytes and diatoms, and cyanobacteria. Cultures will be grown under various environmental conditions to investigate the effects of external forcing functions on gene expression linked to toxicity and growth. After cloning of cDNA of toxigenic strains pooled from cultures grown under these different conditions into plasmid vectors, about 10,000 clones from each taxon will be randomly sequenced for ESTs. Our approach is to annotate the ESTs and attempt to identify genes associated with toxin production. DNA microarrays will be developed for screening of toxigenic and non-toxigenic strains. In addition, the sequence data will be analysed to identify other genes that may be involved in cell regulation or growth, cell cycle events, stress response and the induction of sexuality. Cultures will be grown under various environmental conditions to investigate the effects of external forcing functions on gene expression linked to toxicity and growth. Successful completion of this project will yield new information on microalgal and cyanobacterial genomic sequences for a diversity of taxa and will assist in the diagnosis of genes related to toxin biosynthesis and the formation of toxic blooms.

Development and validation of technical and economic feasibility of a multi MW Wave Dragon offshore wave energy converter (WAVE DRAGON MW)

Objective: The Wave Dragon is a slack-moored wave energy converter of the overtopping type. It is by far the most powerful wave energy converter and at the same time one of the most energy efficient and economic devices under development today. Since March 2003 a 20kW scale 1:4.5 prototype of a 7MW Wave Dragon has been tested as the world's first floating grid connected wave energy converter. The project will develop the Wave Dragon technology further from the tested all steel-built 20kW prototype to a full size composite built 7MW unit and by testing validate the technical and economic feasibility. The RTD-part of the project will: - Develop Wave Dragon's energy absorbing structure, the low head turbine power take-off system and the control systems. An additional reservoir placed above the existing reservoir level will also be developed. The result of these changes to the overall design will be a significant increase in power production and a reduction in O&M cost. The development of the 7MW unit will be based on the knowledge base established through the tests with the 20kW prototype and the design process will comprise several innovative elements utilizing the O&M experience from the 20kW prototype tests. - Develop cost effective construction methods and establish the optimal combination of in situ cast concrete, post- stressed reinforcement and pre-stressed concrete elements - Develop new supplementary environmental friendly water hydraulic power take-off systems - Demonstrate reliable and cost effective installation procedures and O&M schemes - Establish the necessary basis for design codes and recommendations for floating multi MW wave energy converters. The test program will demonstrate the availability, power production predictability, power production capability and medium to long term electricity generation costs at 0.052EUR/kWh in a wave climate of 24kW/m, which could be found relatively close to the cost at the major part of the Atlantic coast.

A Long-term Biodiversity, Ecosystem and Awareness Research Network (Alter-Net)

This Network of Excellence (Noel) will create a European long-term inter-disciplinary research facility for research on the complex relationship between ecosystems, biodiversity and society. It will provide research support for policy assessment and development on the conservation and sustainable use of biodiversity in the European Union, and a stable facility for information retrieval and reporting on biodiversity-related issues. It will achieve this by implementing research, management and cultural changes within and between its component organisations, and through the development of integrated research agendas that will focus the research activities of its members on priority policy issues. The result will be a unique inter-disciplinary network linking a variety of stakeholders including research scientists, science communicators, policy makers and the public. In order to ensure durable integration of 24 partners from 17 countries, this Noël will build on 4 existing co-operative programmes that deal with complementary aspects of biodiversity research. These are PEER/CONNECTJLTER, ECSITE and ECNC.A novel approach to integration of ecological and socio-environmental methodologies will be developed, recognising the fact that biodiversity research should be done only in the context of ecosystems and their long-term dynamics. To achieve this, the core research undertaken by the Noël will be structured around a common framework based on the Drivers-Pressures-State-Impact-Response (DPSIR) model. This framework will ensure that research contributes directly to our understanding of the inter-relationship between biodiversity and the services it provides to society, and vice versa. The framework, and the research it supports, will also facilitate the long-term institutional changes that will be necessary to accomplish the ALTER-net objectives for durable integration. Prime Contractor: Natural Environment Research Council, Swindon, UK.

Cost effective inspection and structural maintenance for ship safety and environmental protection throughout its life cycle (CAS)

Objective: For oil tankers to be more environmentally friendly along their life cycle, IMO has set forth a condition assessment scheme 'CAS' for single hull tankers and is now working to develop a similar type of codefor double hull tankers, which involve huge amounts of measurement information. Performing thoseinspections efficiently requires processing measurement information on a real time basis, resulting incost savings because fast assessment of the ship condition and decision-making could be done while theship is still in the dock for maintenance.Measurement information consists of thickness measurements, visual assessment of coating and cracksdetection. In the existing situation, because there is no standardization of data, it is recorded manuallyon ship drawings or tables, which are very difficult to handle. Measurement information takes a longtime to report and to analyse, leading to some repairs being performed at the next docking of the ship.The system to be developed in this project includes such innovative features as: development of a simplified andflexible ship electronic model which can be refined to fit the needs of inspections, addition of measurementinformation in this ship model, automatic updating of the measurement information in the ship model, integrationof robotics, easy handling of measurement information using virtual reality, immediate worldwide access. Systematic comparison and consistency checks of measurement campaigns will trigger electronic alerts. Repairdecisions and residual lifetime of the structure will be calculated with modern methods of risk based maintenance modelling, with the interesting feature that the model will be updated after each measurementcampaign. The system to be developed is applicable to any ship type, but, due to the current focus on tankers and bulkcarriers, these ships will be used as the main case studies.

European Optimised Pantograph Catenary Interface (EUROPAC)

Objective: Europac will gather major European railway stakeholders around a research project on vehicle-infrastructure interaction through the pantograph-catenary contact. The project aims at enhancing interoperability between pantographs and catenaries all over Europe, decreasing the number of incidents related to this system, and reducing maintenance costs by improving preventive maintenance and diminishing corrective maintenance. On that purpose, Europac will develop a comprehensive system composed of a joint interoperable software, an on-board monitoring system and a track-side monitoring station. The Europac software is designed to predict the interoperability between any present and future pantograph and catenary. Moreover, it is intended to take into account up to now unaddressed effects of deteriorated conditions such as extreme temperatures, cross-winds, wear or defects in devices. The on-board monitoring system aims at detecting defects in a catenary, identifying their origins and evaluating their seriousness. The goal of the track-side monitoring station is to evaluate both compatibility and quality of a pantograph coming into a network. The two systems will combine human-like expert-systems with real-time analyses. Europac's contribution to integration of European railways is manifold: - At the regulation level, it will help refining interoperability specifications and standards and defining new ones. - At the industrial level, it will help manufacturers to comply with interoperability requirements while reducing their development costs. - At the operational level, it will allow railway operators and infrastructure managers to both increase interoperability and reinforce reliability of their rolling stocks and infrastructures. Increased productivity along with economies of scale allowed by interoperability will radically improve competitiveness of the railway transport, thus reversing the trend in favour to this environmentally-friendly mode of transport.

Sustainable energy management systems (SEMS)

Objective: The aim of this project is to turn 4 core communities (Germany, Austria, Luxemburg, Poland) with clearly defined system borders and 14 - 20.000 inhabitants each into CONCERTO communities. A mix of different EE and RES demonstrations (including refurbishment of old buildings, eco-buildings and polygeneration, all underpinned with complete business plans) will allow to avoid about 300 GWh/yr end energy from fossil sources, thus avoiding 94.000 tons CO2/yr, and saving 22.9 mio Euro/yr of disbursements for extra-communal electricity and heat deliveries. The application of the Decentralised Energy Management System (DEMS) will allow for local and inter-communal operation, monitoring and control of energy consumption, storage and generation units and grids, including DSM and LCP, thereby exploring a EE potential of at least 5Prozent. The target in RES coverage for 2010 is of resp. 39 to 62Prozent of the then remaining electricity and heat demand. EnerMAS, a low-threshold version of the European environmental management system.

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